Oxidative stress and antioxidant parameters in neutropenic patients secondary to chemotherapy

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dc.authoridGUREL, ALI/0000-0001-8087-8814
dc.authoridElkıran, Emin Tamer/0000-0001-6681-7249
dc.authoridUstundag, Bilal/0000-0001-6621-2450
dc.authorwosidGUREL, ALI/V-7349-2017
dc.authorwosidÜSTÜNDAĞ, BİLAL/V-9780-2018
dc.authorwosidElkıran, Emin Tamer/ABI-8192-2020
dc.contributor.authorDogantekin, Akif
dc.contributor.authorGurel, Ali
dc.contributor.authorUstundag, Bilal
dc.contributor.authorIlhan, Selcuk
dc.contributor.authorElkiran, Emin Tamer
dc.date.accessioned2024-08-04T20:41:39Z
dc.date.available2024-08-04T20:41:39Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Neutropenia is a serious adverse event that necessitates dosage reduction in patients receiving chemotherapy. In this study, we evaluated the oxidative stress and antioxidant parameters in neutropenic patients after chemotherapy both during the neutropenic period and after successful treatment of neutropenia with filgrastim. Methods: We studied paraoxonase (PON1), arylesterase (ARE), malondialdehyde (MDA), high-density lipoprotein (HDL), lactate dehydrogenase (LDH), and alkaline phosphatase (ALP) in addition to routine biochemical and hematologic parameters. SPSS 12.0 was used for statistical evaluation of data (SPSS, Chicago, IL, USA). Results: In our study, PON1, HDL, and LDH levels during the period of active neutropenia were statistically significantly higher than these levels were after resolution of neutropenia (P<0.05); MDA and ALP levels were statistically significantly lower during the period of active neutropenia (P<0.05). Conclusions: Overall, free oxygen radicals (FOR) were increased and antioxidant parameters were decreased with resolution of neutropenia. This is probably due to FOR produced by the increased number of neutrophils rather than tumor burden.en_US
dc.identifier.endpage313en_US
dc.identifier.issn1682-024X
dc.identifier.issue2en_US
dc.identifier.pmid27182229en_US
dc.identifier.scopus2-s2.0-84962791699en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage309en_US
dc.identifier.urihttps://hdl.handle.net/11616/97259
dc.identifier.volume32en_US
dc.identifier.wosWOS:000373939800010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherProfessional Medical Publicationsen_US
dc.relation.ispartofPakistan Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectMalondialdehydeen_US
dc.subjectNeutropenia secondary to chemotherapyen_US
dc.subjectOxidative stressen_US
dc.subjectParaoxonaseen_US
dc.titleOxidative stress and antioxidant parameters in neutropenic patients secondary to chemotherapyen_US
dc.typeArticleen_US

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