Effects of noopept on cognitive functions and pubertal process in rats with diabetes

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dc.authoridGürbüz, Perihan/0000-0002-6632-9197
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridYildiz, Azibe/0000-0001-5686-7867;
dc.authorwosidTaşlıdere, Aslı/ABI-8274-2020
dc.authorwosidGürbüz, Perihan/Y-4833-2018
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidYildiz, Azibe/ABI-7998-2020
dc.authorwosidDurhan, Merve/JOK-8847-2023
dc.contributor.authorGurbuz, Perihan
dc.contributor.authorDuzova, Halil
dc.contributor.authorYildiz, Azibe
dc.contributor.authorCakan, Pinar
dc.contributor.authorKaya, Gul Busra
dc.contributor.authorBag, Harika Gozde Gozukara
dc.contributor.authorDurhan, Merve
dc.date.accessioned2024-08-04T20:46:05Z
dc.date.available2024-08-04T20:46:05Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Type 1 diabetes (T1DM) is a common chronic disease in childhood. Increasing insulin resistance in puberty gives rise to higher doses of insulin usage in treatment. Of this reason new approaches in treatment are needed. Noopept researches suggest it to have anti-diabetic properties. We tried to determine the effects of noopept on pubertal diabetes. Main method: The research was made with 60 prepubertal, 28 day-old, male, Sprague Dawley rats. The rats were divided into randomised 6 groups (n = 10/group). i) Control, ii) Diabetes Control, iii) Noopept Control, iv) Diabetes + Noopept, v) Diabetes + Insulin, vi) Diabetes + Insulin + Noopept. T1DM model was induced by streptozotocin on postnatal 28th day. 0.5 mg/kg noopept and 1 IU insulin were administered intraperitoneally for 14 days. Blood glucose and body weight measurements, puberty follow-up and MWM tests were performed. Hippocampus, hypothalamus and testis were evaluated histologically. Hypothalamic GnRH and kisspeptin were studied immunohistochemically. Serum LH, FSH and insulin, hippocampal homogenate NGF and BDNF levels were determined by ELISA. Key findings: Delayed puberty was normalized by noopept (p < 0.05). Blood glucose levels were lower in noopept-administered diabetic groups (p < 0.05). Noopept decreased HOMA-IR in insulin administered diabetic group (p < 0.05). Number of degenerated cells in hippocampus and testis were higher in diabetes control group when compared with other groups (p < 0.05). GnRH immunoreactivity in Diabetes + Noopept group was increased when compared to insulin + noopept group (p = 0.018). There was no difference in kisspeptin, serum LH, FSH, hippocampal NGF-BDNF levels and spatial learning assessment among groups (p > 0.05). Significance: Noopept may have positive effect in treatment of pubertal diabetes.en_US
dc.description.sponsorshipTUBITAK [215S629]en_US
dc.description.sponsorshipThis work was supported by the TUBITAK (project number 215S629).en_US
dc.identifier.doi10.1016/j.lfs.2019.116698
dc.identifier.issn0024-3205
dc.identifier.issn1879-0631
dc.identifier.pmid31356906en_US
dc.identifier.scopus2-s2.0-85069807238en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.lfs.2019.116698
dc.identifier.urihttps://hdl.handle.net/11616/98885
dc.identifier.volume233en_US
dc.identifier.wosWOS:000484035300023en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofLife Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNoopepten_US
dc.subjectPubertyen_US
dc.subjectPubertal timingen_US
dc.subjectType 1 diabetesen_US
dc.titleEffects of noopept on cognitive functions and pubertal process in rats with diabetesen_US
dc.typeArticleen_US

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