Is preimplantation genetic diagnosis the ideal embryo selection method in aneuploidy screening?

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dc.authorwosidYUMRU, Ayse Ender/HMV-6766-2023
dc.contributor.authorSahin, Levent
dc.contributor.authorBozkurt, Murat
dc.contributor.authorSahin, Hilal
dc.contributor.authorGurel, Aykut
dc.contributor.authorYumru, Ayse Ender
dc.date.accessioned2024-08-04T20:39:53Z
dc.date.available2024-08-04T20:39:53Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTo select cytogenetically normal embryos, preimplantation genetic diagnosis (PGD) aneuploidy screening (AS) is used in numerous centers around the world. Chromosomal abnormalities lead to developmental problems, implantation failure, and early abortion of embryos. The usefulness of PGD in identifying single-gene diseases, human leukocyte antigen typing, X-linked diseases, and specific genetic diseases is well-known. In this review, preimplantation embryo genetics, PGD research studies, and the European Society of Human Reproduction and Embryology PGD Consortium studies and reports are examined. In addition, criteria for embryo selection, technical aspects of PGD-AS, and potential noninvasive embryo selection methods are described. Indications for PGD and possible causes of discordant PGD results between the centers are discussed. The limitations of fluorescence in situ hybridization, and the advantages of the array comparative genomic hybridization are included in this review. Although PGD-AS for patients of advanced maternal age has been shown to improve in vitro fertilization outcomes in some studies, to our knowledge, there is not sufficient evidence to use advanced maternal age as the sole indication for PGD-AS. PGD-AS might be harmful and may not increase the success rates of in vitro fertilization. At the same time PGD, is not recommended for recurrent implantation failure and unexplained recurrent pregnancy loss. Copyright (C) 2014, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights reserved.en_US
dc.identifier.doi10.1016/j.kjms.2014.05.008
dc.identifier.endpage498en_US
dc.identifier.issn1607-551X
dc.identifier.issue10en_US
dc.identifier.pmid25438679en_US
dc.identifier.scopus2-s2.0-84908228676en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage491en_US
dc.identifier.urihttps://doi.org/10.1016/j.kjms.2014.05.008
dc.identifier.urihttps://hdl.handle.net/11616/96577
dc.identifier.volume30en_US
dc.identifier.wosWOS:000344172400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Taiwanen_US
dc.relation.ispartofKaohsiung Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAneuploidyen_US
dc.subjectChromosomal anomaliesen_US
dc.subjectIn vitro fertilizationen_US
dc.subjectPreimplantation genetic diagnosisen_US
dc.titleIs preimplantation genetic diagnosis the ideal embryo selection method in aneuploidy screening?en_US
dc.typeReview Articleen_US

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