THE RELATION BETWEEN MODIFIED SYSTEMIC INFLAMMATION SCORE AND PROGNOSTIC MARKERS OF GASTROINTESTINAL STROMAL TUMORS

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dc.contributor.authorCanlıkarakaya, Fırat
dc.contributor.authorOcaklı, Serhat
dc.contributor.authorCeylan, Cengiz
dc.contributor.authorGöktaş, Abidin
dc.contributor.authorGüler, İlkay
dc.contributor.authorTerzioğlu, Serdar Gökay
dc.date.accessioned2024-08-04T19:54:33Z
dc.date.available2024-08-04T19:54:33Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective Gastrointestinal stromal tumours are tumours of mesenchymal origin that can be located along the gastrointestinal tract. In this study, the role of Modified systemic inflammation score in predicting the prognosis of these tumours was investigated. Material and Method 115 patients diagnosed with Gastrointestinal Stromal Tumor (GIST) who underwent surgery at Ankara City Hospital between June 1, 2019 and December 1, 2022 were examined. Tumor location, size, presence of rupture-bleeding-necrosis, Ki-67 level, mitotic index and preoperative albumin, lymphocyte and monocyte levels were evaluated. mSIS score was grouped as 0, 1 and 2. The relationship between mSIS and Ki- 67 index and the presence of rupture, necrosis and bleeding was investigated. Results Out of 115 patients, 68 (59 %) were male, 47 (41 %) were female, with an average age of 62.5 (± 12.67) years. Tumor locations: stomach (64.3 %), small intestine (26 %), colon (5.2 %), esophagus (1.8 %), pancreas (1.8 %), and ovary (0.9 %). Necrosis was in 25 (30.7 %), hemorrhage in 67 (58.7 %), rupture in 19 (16.8 %), and the mean Ki-67 level was 9.09 (± 10.64). 63 (54.8 %) patients had mSIS 0, 29 (25.2 %) had mSIS 1, and 23 (20 %) had mSIS 2. Statistical analysis found a significant correlation between mSIS and necrosis, but not with other parameters. Conclusion The mSIS score is a valuable score showing inflammation in the body and has been shown to be associated with the prognosis of many malignancies. In our study, the presence of necrosis in the tumour was found to be associated with the mSIS score. Although this result alone is not sufficient to predict the prognosis, it is thought to be an issue that may open the door to new studies.en_US
dc.identifier.doi10.17343/sdutfd.1382872
dc.identifier.endpage702en_US
dc.identifier.issn1300-7416
dc.identifier.issn2602-2109
dc.identifier.issue4en_US
dc.identifier.startpage698en_US
dc.identifier.trdizinid1219097en_US
dc.identifier.urihttps://doi.org/10.17343/sdutfd.1382872
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1219097
dc.identifier.urihttps://hdl.handle.net/11616/89920
dc.identifier.volume30en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofSüleyman Demirel Üniversitesi Tıp Fakültesi Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleTHE RELATION BETWEEN MODIFIED SYSTEMIC INFLAMMATION SCORE AND PROGNOSTIC MARKERS OF GASTROINTESTINAL STROMAL TUMORSen_US
dc.typeArticleen_US

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