Protective effect of leflunomide against oxidative intestinal injury in a rodent model of sepsis

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dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186;
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidKARAMAN, Abdurrahman/G-7825-2016
dc.authorwosidFadillioglu, Ersin/K-3817-2019
dc.contributor.authorOzturk, Erdogan
dc.contributor.authorSurucu, Murat
dc.contributor.authorKaraman, Abdurrahman
dc.contributor.authorSamdanci, Emine
dc.contributor.authorFadillioglu, Ersin
dc.date.accessioned2024-08-04T20:39:41Z
dc.date.available2024-08-04T20:39:41Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Sepsis is defined as an uncontrolled inflammatory response in a host. The process may lead to severe sepsis, multisystem organ failure and even death. Leflunomide has important immunomodulatory and anti-inflammatory effects, which may mitigate host response to bacterial translocation. The goal of our study was to measure the effects leflunomide administration had on a variety of biochemical markers upregulated in systemic inflammatory response syndrome, sepsis, and multiple organ failure syndrome. Materials and methods: Wistar albino type rats were randomly divided into five groups: control, sham, leflunomide, sepsis, and sepsis + leflunomide. Sepsis was achieved by means of the cecal ligation and puncture method. Leflunomide 2 x 10 mg/kg/d was administered before the experiment. At the end of 24 h, the tissue levels of superoxide dismutase, catalase activity, malondialdehyde, nitric oxide, and protein carbonyl were measured. Results: The level of the bowel superoxide dismutase and catalase levels of the sepsis group is significantly lower than those of the control, sham, and leflunomide groups (P < 0.05). Malondialdehyde, nitric oxide, and protein carbonyl levels are significantly higher in sepsis compared with other groups (P < 0.05). Conclusions: Leflunomide's prevention of protein and lipid peroxidation was observed in septic bowel tissue. Use of leflunomide could have protective effects against both the onset and the progressive stages of sepsis. Crown Copyright (c) 2014 Published by Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jss.2013.11.005
dc.identifier.endpage615en_US
dc.identifier.issn0022-4804
dc.identifier.issn1095-8673
dc.identifier.issue2en_US
dc.identifier.pmid24484905en_US
dc.identifier.scopus2-s2.0-84900560681en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage610en_US
dc.identifier.urihttps://doi.org/10.1016/j.jss.2013.11.005
dc.identifier.urihttps://hdl.handle.net/11616/96447
dc.identifier.volume187en_US
dc.identifier.wosWOS:000332770600033en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofJournal of Surgical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSepsisen_US
dc.subjectLeflunomideen_US
dc.subjectOxidative stressen_US
dc.titleProtective effect of leflunomide against oxidative intestinal injury in a rodent model of sepsisen_US
dc.typeArticleen_US

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