The REDOX balance in the prefrontal cortex is positively modulated by aerobic exercise and altered by overfeeding

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dc.contributor.authorSilva, Deyvison Guilherme Martins
dc.contributor.authorde Santana, Jonata Henrique
dc.contributor.authorBernardo, Elenilson Maximino
dc.contributor.authorFernandes, Matheus Santos de Sousa
dc.contributor.authorYagin, Fatma Hilal
dc.contributor.authorAl-Hashem, Fahaid
dc.contributor.authorFernandes, Mariana P.
dc.date.accessioned2026-04-04T13:34:40Z
dc.date.available2026-04-04T13:34:40Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractWhile obesity rates increase worldwide, physical activity levels are reduced. Obesity and physical inactivity may be inversely related to the production of reactive oxygen species (ROS) and cause oxidative stress in the central nervous system. In this study, we aimed to investigate the effects of aerobic physical exercise on the oxidative balance of the prefrontal cortex of rats subjected to overnutrition during lactation. For this, male Wistar rats were subjected to overnutrition during lactation between postnatal day 3 to 21. On postnatal day 23, the two groups of animals were subdivided into trained and untrained animals. Trained rats were subjected to a treadmill training protocol for four weeks, five days/week, 60 min/day, at 50% of maximum running capacity. Our findings demonstrate that overnutrition impairs REDOX balance in the prefrontal cortex through increased prooxidants and reduced antioxidant defenses. On the contrary, exercise tends to restore most of these measures to control levels, possibly due to the increase in mRNA levels of Sirt1 and reduction in Il-6 in the prefrontal cortex. Overnutrition causes oxidative stress in the prefrontal cortex, while exercise re-covers most of its adverse effects through activating anti-inflammatory mechanisms.
dc.description.sponsorshipCoordenao de Aperfeioamento de Pessoal de Nvel Superior - Brasil (CAPES) [PNURSP2025R145]; Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia; Prince Sultan University
dc.description.sponsorshipThe authors express their gratitude to Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2025R145), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia for funding this research. In addition, the authors would like to thank Prince Sultan University for its support during the conduct of the research.
dc.identifier.doi10.1038/s41598-025-99303-2
dc.identifier.issn2045-2322
dc.identifier.issue1
dc.identifier.pmid40259099
dc.identifier.scopus2-s2.0-105003164531
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1038/s41598-025-99303-2
dc.identifier.urihttps://hdl.handle.net/11616/109320
dc.identifier.volume15
dc.identifier.wosWOS:001472136200010
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNature Portfolio
dc.relation.ispartofScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectBrain
dc.subjectExercise
dc.subjectObesity
dc.subjectOxidative stress
dc.titleThe REDOX balance in the prefrontal cortex is positively modulated by aerobic exercise and altered by overfeeding
dc.typeArticle

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