The relationship between heart rate recovery and heart rate variability in coronary artery disease

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dc.authoridCelik, Turgay/0000-0001-8418-0130;
dc.authorwosidKilic, Ayhan/N-7387-2013
dc.authorwosidCelik, Turgay/I-2981-2019
dc.authorwosidKilic, Ayhan/A-6577-2018
dc.contributor.authorEvrengul, H
dc.contributor.authorTanriverdi, H
dc.contributor.authorKose, S
dc.contributor.authorAmasyali, B
dc.contributor.authorKilic, A
dc.contributor.authorCelik, T
dc.contributor.authorTurhan, H
dc.date.accessioned2024-08-04T20:15:21Z
dc.date.available2024-08-04T20:15:21Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Reduced heart rate recovery (HRR) in coronary artery disease (CAD) is predictive of increased cardiovascular mortality and is related to reduced parasympathetic tonus. Objective: To investigate HRR and heart rate variability (HRV) measured at steady state condition and the relationship between these two parameters in CAD. Materials and Methods: In our study, we enrolled 33 (28 males, mean age 52.4 +/- 9.6 years) patients with CAD who did not have heart failure, atrial fibrillation, pacemaker, and any disease state that could affect the autonomic functions and 38 age-matched healthy subjects (21 males, mean age 48.3 +/- 7.8 years). All the patients underwent submaximal treadmill exercise testing (Bruce protocol). HRR was calculated by subtracting the heart rate values at the 1st, 2nd, and 3rd minutes of the recovery phase from the peak heart rate (HRR1, HRR2, HRR3). Before exercise testing, short-term steady state HRV analyses of all subjects were obtained with the time- and frequency-domain methods and were correlated to HRR. For frequency-domain analysis, low-frequency HRV (LF, 0.004-0.15 Hz), high-frequency HRV (HF, 0.15-0.5 Hz), and LF/HF ratio were measured for 5 minutes in the morning. For time-domain analysis, standard deviation of the normal-to-normal NN intervals (SDNN), square root of the mean squared differences of successive N-N intervals (RMSSD), and proportion derived by dividing the number of interval differences of successive N-N intervals greater than 50 ms by the total number of N-N intervals (pNN50) were obtained. Only HRR3 was used for the correlation analysis. Results: In CAD groups, the HF, an indicator of parasympathetic activation, was significantly reduced, whereas the LF and LF/HF values, which are indicators of sympathetic activity, were increased (P = 0.0001 for each parameter). The time-domain parameters SDNN, RMSSD, and pNN50 were significantly reduced in the patient group (P = 0.0001, P = 0.009, and P = 0.0001, respectively). Similar to the HRV parameters, the HRR1, HRR2, and HRR3 values were significantly reduced in the patient group (P = 0.0001 for each parameter). We observed a significant negative correlation between HRR3 and LF (r =-0.67, P = 0.0001) and between HRR3 and LF/HF (r =-0.62, P < 0.0001), while there was a significant positive correlation between HRR3 and HF, SDNN, RMSSD, and pNN50 (r = 0.69, P = 0.0001; r = 0.41, P = 0.0001; r = 0.31, P = 0.008; and r = 0.44, P = 0.0001). Conclusions: HRR and HRV are significantly reduced in CAD. The reduction in HRR is parallel to the changes in HRV parameters. HRR, which can be measured easily in the recovery phase of exercise testing, can be used to detect the depression of parasympathetic tonus and to evaluate the basal autonomic balance in this patient group.en_US
dc.identifier.doi10.1111/j.1542-474X.2006.00097.x
dc.identifier.endpage162en_US
dc.identifier.issn1082-720X
dc.identifier.issn1542-474X
dc.identifier.issue2en_US
dc.identifier.pmid16630090en_US
dc.identifier.scopus2-s2.0-33645326223en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage154en_US
dc.identifier.urihttps://doi.org/10.1111/j.1542-474X.2006.00097.x
dc.identifier.urihttps://hdl.handle.net/11616/94327
dc.identifier.volume11en_US
dc.identifier.wosWOS:000236391800009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAnnals of Noninvasive Electrocardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectheart rate recoveryen_US
dc.subjectheart rate variabilityen_US
dc.subjectcoronary artery diseaseen_US
dc.titleThe relationship between heart rate recovery and heart rate variability in coronary artery diseaseen_US
dc.typeArticleen_US

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