Pd-NHC complex catalyzed C-H bond activation reactions of caffeine and 2-isobuthylthiazole
dc.authorid | Boulebd, Houssem/0000-0002-7727-8583 | |
dc.authorid | Bulut, Fatih/0000-0001-6603-2468 | |
dc.authorid | Khan, Siraj/0000-0003-1948-452X | |
dc.authorid | yasar, sedat/0000-0001-7285-2761 | |
dc.authorid | Bugday, Nesrin/0000-0002-3882-035X | |
dc.authorid | Oz, Erdinc/0000-0003-4321-8264 | |
dc.authorwosid | Rehman, Asim Ur/J-4207-2015 | |
dc.authorwosid | Boulebd, Houssem/HMP-2883-2023 | |
dc.authorwosid | Oz, Erdinc/GXW-0937-2022 | |
dc.authorwosid | Bulut, Fatih/F-7201-2013 | |
dc.contributor.author | Bugday, Nesrin | |
dc.contributor.author | Khan, Siraj | |
dc.contributor.author | Yasar, Sedat | |
dc.contributor.author | Bulut, Fatih | |
dc.contributor.author | Boulebd, Houssem | |
dc.contributor.author | Karabiyik, Hande | |
dc.contributor.author | Karabiyik, Hasan | |
dc.date.accessioned | 2024-08-04T20:52:14Z | |
dc.date.available | 2024-08-04T20:52:14Z | |
dc.date.issued | 2022 | |
dc.department | İnönü Üniversitesi | en_US |
dc.description.abstract | A series of new Pd-NHC complexes were synthesized, characterized, and utilized as catalysts on 8-(hetero)ary-lation of xanthines and C-5 (hetero)arylation of 2-isobuthylthiazole. All the synthesized derivatives were characterized by NMR, Q-TOF-LC/MS, FTIR, and X-ray (for 4a, 5a, and 5b) analysis. In addition, DFT calculations and computational NBO studies for Pd-NHC complexes were examined, and HOMO and LUMO energy levels and electron density of each Pd-NHC complex were defined. 4a-c and 5a-b complexes showed good catalytic activity in C-H bond activation reactions. DFT studies have also been conducted to examine the reaction mechanism following the CMD pathway. Complex 5a was chosen as a representative catalyst for the reaction of unsubstituted phenyl with caffeine and 2-isobuthylthiazole. Although the delta E values of the complexes are so close, slight difference in the catalytic activity were observed for 4a-c and 5a-b. Since this low delta E value facilitates the oxidative addition reaction of (hetero)aryl bromides, thanks to this catalytic system, new 8-(hetero)aryl xan-thines and 5-(hetero)aryl thiazole derivatives could be synthesized with high yields and low catalyst loading. | en_US |
dc.description.sponsorship | Inonu University Research Council [FYL-2020-2131]; Dokuz Eylul University [2010. KB.FEN.13] | en_US |
dc.description.sponsorship | The authors acknowledge Inonu University Research Council for partially supporting the study by the project number of FYL-2020-2131, and Dokuz Eylul University for the use of the Rigaku Oxford Xcalibur Eos Diffractometer (purchased under University Research Grant No. 2010. KB.FEN.13). | en_US |
dc.identifier.doi | 10.1016/j.mcat.2022.112590 | |
dc.identifier.issn | 2468-8231 | |
dc.identifier.scopus | 2-s2.0-85135828098 | en_US |
dc.identifier.scopusquality | Q2 | en_US |
dc.identifier.uri | https://doi.org/10.1016/j.mcat.2022.112590 | |
dc.identifier.uri | https://hdl.handle.net/11616/100838 | |
dc.identifier.volume | 530 | en_US |
dc.identifier.wos | WOS:000843516700001 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.ispartof | Molecular Catalysis | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Pd-NHC complexes | en_US |
dc.subject | C -H activation | en_US |
dc.subject | 8-(hetero)aryl xanthines | en_US |
dc.subject | Caffeine | en_US |
dc.subject | Thiazole | en_US |
dc.title | Pd-NHC complex catalyzed C-H bond activation reactions of caffeine and 2-isobuthylthiazole | en_US |
dc.type | Article | en_US |