Pre-transplant predictors of 3-Month survival following liver transplantation for acute liver failure in adult and pediatric patients in Turkiye

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dc.contributor.authorTuran, Ilker
dc.contributor.authorAkarca, Ulus Salih
dc.contributor.authorAladag, Murat
dc.contributor.authorHarputluoglu, Murat
dc.contributor.authorYilmaz, Sezai
dc.contributor.authorGencdal, Genco
dc.contributor.authorArikan, Cigdem
dc.date.accessioned2026-04-04T13:34:41Z
dc.date.available2026-04-04T13:34:41Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractThis multicenter retrospective study analyzed 336 patients (236 adults, 100 children) who underwent liver transplantation (LT) for acute liver failure (ALF) between 2002 and 2019 across 14 centers in Turkiye. The aim was to evaluate pretransplant factors influencing short-term posttransplant survival. Median MELD and PELD scores were 31 and 30, respectively. The most common ALF etiologies were viral, indeterminate, and drug-induced causes. Living donor liver transplantation (LDLT) was more common in children (86.0%) than adults (57.2%). Mean posttransplant survival was 166 +/- 9 months in children and 117 +/- 6 months in adults. In adults, LDLT significantly improved survival compared to deceased donor LT (DDLT), with survival of 135 vs. 89 months (p=0.0012). Although pediatric LDLT recipients had longer mean survival than DDLT recipients (167 vs. 132 months), this difference was not statistically significant (p=0.5959). Three-month mortality was associated with low albumin and grade 4 hepatic encephalopathy (HE) in children. In adults, independent predictors of early mortality included DDLT, serum sodium >140 mEq/L, MELD >35, pH <7.3, and grade 4 HE. Our data suggest that LDLT may offer a survival advantage, particularly in adults with ALF. Identifying pretransplant risk factors is essential for improving early outcomes and guiding clinical decision-making.
dc.identifier.doi10.1038/s41598-025-11298-y
dc.identifier.issn2045-2322
dc.identifier.issue1
dc.identifier.orcid0000-0002-0794-2741
dc.identifier.orcid0000-0002-2840-2429
dc.identifier.scopus2-s2.0-105011150075
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1038/s41598-025-11298-y
dc.identifier.urihttps://hdl.handle.net/11616/109340
dc.identifier.volume15
dc.identifier.wosWOS:001555374800027
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherNature Portfolio
dc.relation.ispartofScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectAcute liver failure
dc.subjectLiver transplantation
dc.subjectLiving donor
dc.titlePre-transplant predictors of 3-Month survival following liver transplantation for acute liver failure in adult and pediatric patients in Turkiye
dc.typeArticle

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