Moderate aerobic training counterbalances the deleterious effect of undernutrition on oxidative balance and mitochondrial markers

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dc.authorscopusid57198780400
dc.authorscopusid56769933900
dc.authorscopusid58175511800
dc.authorscopusid57214470162
dc.authorscopusid57222601949
dc.authorscopusid26323200100
dc.authorscopusid57211715604
dc.contributor.authorde Sousa Fernandes M.S.
dc.contributor.authorda Silva Pedroza A.A.
dc.contributor.authorMartins Silva D.G.
dc.contributor.authorde Andrade Silva S.C.
dc.contributor.authorPereira A.R.
dc.contributor.authorFernandes M.P.
dc.contributor.authorYagin F.H.
dc.date.accessioned2024-08-04T20:03:30Z
dc.date.available2024-08-04T20:03:30Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe state of Maternal Protein Malnutrition (MPM) is associated with several deleterious effects, including inflammatory processes and dysregulation in oxidative balance, which can promote neurodegeneration. On the other hand, it is known that aerobic exercise can promote systemic health benefits, combating numerous chronic diseases. Therefore, we evaluate the effect of aerobic exercise training (AET) on indicators of mitochondrial bioenergetics, oxidative balance, endoplasmic reticulum stress, and neurotrophic factor in the prefrontal cortex of malnourished juvenile Wistar rats. Pregnant Wistar rats were fed with a diet containing 17% or 8% casein during pregnancy and lactation. At 30 days of life, male offspring were divided into 4 groups: Low-Protein Control (LS), Low-Protein Trained (LT), Normoprotein Control (NS), and Normoprotein Trained (NT). The trained groups performed an AET for 4 weeks, 5 days a week, 1 h a day per session. At 60 days of life, the animals were sacrificed and the skeletal muscle, and prefrontal cortex (PFC) were removed to evaluate the oxidative metabolism markers and gene expression of ATF-6, GRP78, PERK and BDNF. Our results showed that MPM impairs oxidative metabolism associated with higher oxidative and reticulum stress. However, AET restored the levels of indicators of mitochondrial bioenergetics, in addition to promoting resilience to cellular stress. AET at moderate intensity for 4 weeks in young Wistar rats can act as a non-pharmacological intervention in fighting against the deleterious effects of a protein-restricted maternal diet. © The Author(s) 2024.en_US
dc.description.sponsorshipJohns Hopkins University, JHU; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, CAPES; University of Cambridge: 01.08.0655.00; Universal-408403/2016, APQ-0765-4.05/10, APQ-1026-4.09/12en_US
dc.description.sponsorshipThe English text of this paper has been revised by a native person with the following qualifications, MAT (The Johns Hopkins University), RSAdip\u2014TESL (Cambridge University). We thank Dr. Toscano A.E. responsible for the Studies in Nutrition and Phenotypic Plasticity Unit (FINEP number 01.08.0655.00). This work was supported by FACEPE and CNPq (Foundation for the Support of Science and Research from Pernambuco State\u2014Brazil, APQ-0765-4.05/10; APQ-1026-4.09/12; Universal-408403/2016) for the financial support to acquire the equipment and reagents used in this work and scholarships. This study was financed in part by the Coordena\u00E7\u00E3o de Aperfei\u00E7oamento de Pessoal de N\u00EDvel Superior \u2013 Brasil (CAPES) \u2013 Finance Code 001.en_US
dc.identifier.doi10.1038/s41598-024-67887-w
dc.identifier.issn2045-2322
dc.identifier.issue1en_US
dc.identifier.pmid39043767en_US
dc.identifier.scopus2-s2.0-85199282618en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1038/s41598-024-67887-w
dc.identifier.urihttps://hdl.handle.net/11616/91878
dc.identifier.volume14en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNature Researchen_US
dc.relation.ispartofScientific Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBrainen_US
dc.subjectCellular stressen_US
dc.subjectMaternal low protein dieten_US
dc.subjectOxidative stressen_US
dc.subjectPhysical exerciseen_US
dc.titleModerate aerobic training counterbalances the deleterious effect of undernutrition on oxidative balance and mitochondrial markersen_US
dc.typeArticleen_US

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