Artemisinin reduces acute ovarian ischemia-reperfusion injury in rats

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dc.authoridYığman, Zeynep/0000-0003-1985-9280
dc.authoridCEYHAN, MUSERREF SEYMA/0000-0003-1346-5993
dc.authoridOsmanlioglu Dag, Suheda Rumeysa/0000-0002-0243-3454
dc.authoridEr, Fatma/0000-0003-3008-1764
dc.authorwosidYığman, Zeynep/HTM-5876-2023
dc.authorwosidCEYHAN, MUSERREF SEYMA/AHE-5225-2022
dc.contributor.authorOsmanlioglu, Seyma
dc.contributor.authorArslan, Mustafa
dc.contributor.authorDag, Rumeysa Osmanlioglu
dc.contributor.authorYigman, Zeynep
dc.contributor.authorCeyhan, Mueserref Seyma
dc.contributor.authorEr, Fatma
dc.contributor.authorKavutcu, Mustafa
dc.date.accessioned2024-08-04T20:54:27Z
dc.date.available2024-08-04T20:54:27Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractArtemisinin (ARS) is well known as an effective agent in the treatment of malaria through the rapid elimination of Plasmodium falciparum parasites. This study aims to investigate the effect of ARS in treating adnexal torsion, one of the most common gynecological surgical emergencies. ARS was administered intraperitoneally once 30 min before unilateral ovarian torsion in two different doses (10 mg/kg vs. 50 mg/kg). Torsion was maintained for 3 h and then held in the detorted state for 3 h. Bilateral adnexectomy was performed to measure antioxidant enzyme activities and oxidant levels on the ipsilateral ovary and to make histopathological and immunohistochemical analyses on the contralateral ovary. Ischemia-reperfusion (I/R) injury dramatically upregulated the activities of CAT, GST, and MDA levels in the ipsilateral ovary, which were all downregulated by ARS treatment. A significant increase in follicular cell degeneration, congestion, and edema in the contralateral ovary was seen in the I/R group, which was significantly reduced with ARS treatment. Furthermore, I/R injury resulted in a significant increase in apoptosis as shown by the increased levels of BAX and CASP-3, and decreased levels of BCL-2 whereas ARS significantly reduced the impact of the injury. Our data, based on a rat I/R injury model, show that both ipsilateral and contralateral ovaries are protected with ARS pretreatment, and 50 mg/kg ARS treatment demonstrates to be more effective than the 10 mg/kg ARS.en_US
dc.identifier.doi10.1016/j.reprotox.2023.108417
dc.identifier.issn0890-6238
dc.identifier.issn1873-1708
dc.identifier.pmid37263547en_US
dc.identifier.scopus2-s2.0-85161504247en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.reprotox.2023.108417
dc.identifier.urihttps://hdl.handle.net/11616/101396
dc.identifier.volume119en_US
dc.identifier.wosWOS:001055534100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofReproductive Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdnexal torsionen_US
dc.subjectArtemisininen_US
dc.subjectOvarian I/R injuryen_US
dc.subjectOvarian ischemia-reperfusion injuryen_US
dc.subjectOvarian torsionen_US
dc.titleArtemisinin reduces acute ovarian ischemia-reperfusion injury in ratsen_US
dc.typeArticleen_US

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