Thyroid pathologies accompanying primary hyperparathyroidism: a high rate of papillary thyroid microcarcinoma

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dc.authoridKutluturk, Koray/0000-0002-7030-4953
dc.authorwosidKutluturk, Koray/S-5493-2019
dc.contributor.authorKutluturk, Koray
dc.contributor.authorOtan, Emrah
dc.contributor.authorYagci, Mehmet Ali
dc.contributor.authorUsta, Sertac
dc.contributor.authorAydin, Cemalettin
dc.contributor.authorUnal, Bulent
dc.date.accessioned2024-08-04T20:39:51Z
dc.date.available2024-08-04T20:39:51Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Thyroid pathologies and non-medullary thyroid cancer often accompany primary hyperparathyroidism (PHPT). The purpose of this study was to examine the association between thyroid diseases, especially micropapillary thyroid cancer, with PHPT. Material and Methods: Data regarding 46 patients who were operated on with a diagnosis of PHPT at Inonu University Faculty of Medicine, General Surgery Clinic between June 2009 and March 2013 were retrospectively analyzed. Age, gender, levels of preoperative calcium, parathyroid hormone and phosphorus, and the histopathological results of the removed parathyroid and thyroid tissues were evaluated. All of the patients had a preoperative diagnosis of PHPT and there was no history of radiation to the head and neck region in any of the patients. Results: Out of the 46 patients who were operated on for PHPT, 39 were female and 7 were male. The mean age was 52.8 years (25-76). Simultaneous thyroidectomy was performed in 35 patients (76.1%) due to an accompanying thyroid disorder. Papillary microcarcinoma was detected in 5 of these 35 (10.9%) patients who underwent thyroidectomy, two of which (40%) were multifocal tumors. The benign thyroid pathologies detected in the remaining 30 (65.2%) cases included lymphocytic thyroiditis in 3, Hashimoto thyroiditis in 1, follicular adenoma in 3 (two of which was Hurtle cell), and nodular colloidal goiter in 23 patients. The preoperative serum phosphate level was significantly higher in the group with papillary thyroid microcarcinoma (p=0.013). Conclusion: In regions where goiter is endemic, thyroid diseases and thyroid papillary microcarcinoma occur in association with PHPT at a higher rate compared to the normal population. Therefore, we believe that patients who are planned for surgery due to PHPT should be thoroughly investigated for the presence of any concomitant malignant thyroid pathologies in the preoperative period. It should also be kept in mind that patients with high blood serum phosphate values may have an increased risk of papillary thyroid microcarcinoma.en_US
dc.identifier.doi10.5152/UCD.2014.2685
dc.identifier.endpage128en_US
dc.identifier.issn2564-6850
dc.identifier.issn2564-7032
dc.identifier.issue3en_US
dc.identifier.pmid25931912en_US
dc.identifier.scopus2-s2.0-84907278850en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage125en_US
dc.identifier.urihttps://doi.org/10.5152/UCD.2014.2685
dc.identifier.urihttps://hdl.handle.net/11616/96560
dc.identifier.volume30en_US
dc.identifier.wosWOS:000420220600003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPrimary hyperparathyroidismen_US
dc.subjectthyroid papillary microcarcinomaen_US
dc.subjectgoiteren_US
dc.titleThyroid pathologies accompanying primary hyperparathyroidism: a high rate of papillary thyroid microcarcinomaen_US
dc.typeArticleen_US

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