The ameliorating effect of cannabinoid type 2 receptor activation on brain, lung, liver and heart damage in cecal ligation and puncture-induced sepsis model in rats

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dc.authoridCakir, Murat/0000-0002-2066-829X
dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authorwosidCakir, Murat/I-8643-2019
dc.authorwosidOkan, Aslı/I-8771-2017
dc.authorwosidTekin, Suat/IZD-9868-2023
dc.authorwosidDoğanyiğit, Züleyha/AAW-2347-2021
dc.authorwosidTekin, Suat/AAG-1440-2021
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.contributor.authorCakir, Murat
dc.contributor.authorTekin, Suat
dc.contributor.authorOkan, Asli
dc.contributor.authorCakan, Pinar
dc.contributor.authorDoganyigit, Zuleyha
dc.date.accessioned2024-08-04T20:46:58Z
dc.date.available2024-08-04T20:46:58Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractUncontrolled infection and increased inflammatory mediators might cause systemic inflammatory response. It is already known that Cannabinoid Type 2 (CB2) receptors, which are commonly expressed in immune cells and in many other tissues, have an effect on the regulation of immune response. In the present study of ours, the effects of CB2 receptor agonist JWH-133 was investigated on cecal ligation and puncture (CLP)-induced polymicrobial sepsis model in rats. In the present study, Sprague-Dawley rats were divided into 5 groups (i.e. the Sham, CLP, JWH-133 0.2 mg/kg, JWH-133 1 mg/kg, and JWH-133 5 mg/kg Groups). Except for the Sham Group, the CLP-induced sepsis model was applied to all groups. The histopathological damage in brain, lung, liver and, heart was examined and the caspase-3, p-NF-kappa B, TNF-alpha, IL-1 beta and IL-6 levels were determined immunohistochemically. The serum TNF-alpha, IL-1 beta, IL-6, IL-10 levels were examined with the ELISA Method. The JWH-133 treatment decreased the histopathological damage in brain, heart, lung, and liver and reduced the caspase-3, p-NF-kappa B, TNF alpha, IL-1 beta, IL-6 levels in these tissues. In addition to this, JWH-133 treatment also decreased the serum TNF-alpha, IL-1 beta, IL-6 levels, which were increased due to CLP, and increased the anti-inflammatory cytokine IL-10 levels. In the present study, it was determined that the CB2 receptor agonist JWH-133 decreases the CLP-induced inflammation, and reduces the damage in brain, lung, liver and heart. Our findings show the therapeutic potential of the activation of CB2 receptors with JWH-133 in sepsis.en_US
dc.description.sponsorshipYozgat Bozok University, Department of Scientific Research Projects, Turkey [6602c-TF/18-229]en_US
dc.description.sponsorshipWe were supported by Yozgat Bozok University, Department of Scientific Research Projects, Turkey (Project no: 6602c-TF/18-229).en_US
dc.identifier.doi10.1016/j.intimp.2019.105978
dc.identifier.issn1567-5769
dc.identifier.issn1878-1705
dc.identifier.pmid31767546en_US
dc.identifier.scopus2-s2.0-85075856324en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.intimp.2019.105978
dc.identifier.urihttps://hdl.handle.net/11616/99081
dc.identifier.volume78en_US
dc.identifier.wosWOS:000510086800053en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Immunopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSepsisen_US
dc.subjectCecal ligation and punctureen_US
dc.subjectCannabinoid type 2 receptoren_US
dc.subjectJWH-133en_US
dc.titleThe ameliorating effect of cannabinoid type 2 receptor activation on brain, lung, liver and heart damage in cecal ligation and puncture-induced sepsis model in ratsen_US
dc.typeArticleen_US

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