Chemistry, structure, and biological roles of Au-NHC complexes as TrxR inhibitors

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dc.authoridGürses, Canbolat/0000-0002-4085-0224
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridAktaş, Aydın/0000-0001-8496-6782
dc.authorwosidGürses, Canbolat/AAA-6825-2019
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.authorwosidAktaş, Aydın/J-6194-2019
dc.contributor.authorKaraaslan, Merve Goksin
dc.contributor.authorAktas, Aydin
dc.contributor.authorGurses, Canbolat
dc.contributor.authorGok, Yetkin
dc.contributor.authorAtes, Burhan
dc.date.accessioned2024-08-04T20:47:05Z
dc.date.available2024-08-04T20:47:05Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn recent years, the preparation of metal complexes and the introduction of biologically active organometalic compounds are new strategies in drug development. For this purpose, generally N-heterocyclic pharmaceutical agents have been used as promising nuclei. Au-containing N-heterocyclic carbene (Au-NHC) derivatives are among the compounds used for this purpose, and their enzyme inhibition, antioxidant activity, antimicrobial and anticancer properties are widely studied. In these studies, the anticancer property of Au-NHC complexes is the most widely studied area. The common result in different studies has been revealed that mitochondrial thioredoxin reductases (TrxR) inhibition is the main pathway in the powerful anticancer effect of many Au-NHC complexes. In TrxR inhibition, the high affinity of gold to sulfur is considered to be the main component of the effect. This review includes the discussions releated to the anticancer activities and TrxR inhibition properties of Au-NHC compounds.en_US
dc.identifier.doi10.1016/j.bioorg.2019.103552
dc.identifier.issn0045-2068
dc.identifier.issn1090-2120
dc.identifier.pmid31911299en_US
dc.identifier.scopus2-s2.0-85078192450en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.bioorg.2019.103552
dc.identifier.urihttps://hdl.handle.net/11616/99154
dc.identifier.volume95en_US
dc.identifier.wosWOS:000512762900065en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofBioorganic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAu-NHC complexesen_US
dc.subjectAnticancer activityen_US
dc.subjectTrxR inhibitorsen_US
dc.subjectEnzymeen_US
dc.titleChemistry, structure, and biological roles of Au-NHC complexes as TrxR inhibitorsen_US
dc.typeArticleen_US

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