The protective cardiac effects of B-myrcene after global cerebral ischemia/reperfusion in C57BL/J6 mouse

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dc.authoridGul, Burcu/0000-0002-9122-8953
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authoridCETIN, Asli/0000-0003-3902-3210
dc.authorwosidGul, Burcu/V-9452-2018
dc.contributor.authorBurcu, Gul Baykalir
dc.contributor.authorOsman, Ciftci
dc.contributor.authorAsl, Cetin
dc.contributor.authorNamik, Oztanir Mustafa
dc.contributor.authorNese, Basak Turkmen
dc.date.accessioned2024-08-04T20:42:33Z
dc.date.available2024-08-04T20:42:33Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPURPOSE: To investigate the protective effect of beta-myrcene (MYR) on oxidative and histological damage in mice heart tissue caused global cerebral ischemia/reperfusion (IR) in C57BL/J6 mice. METHODS: Animals(n=40) were randomly divided into four groups: (1)control, (2)IR, (3)MYR and (4)MYR+IR. The control group was received 0.1% carboxymethyl cellulose as a vehicle following a medial incision without carotid occlusion. In the IR group, the bilateral carotid arteries were clipped for 15min, and treated with the vehicle intraperitoneally(ip) for 10 days. MYR (200mg/kg) was received dissolved in 0.1%CMC for 10 days. In the MYR+IR group, the IR model was applied exactly as in the IR group, and then they were treated with MYR 10 days. RESULTS: The cerebral IR caused oxidative damage (increase TBARS, decrease antioxidant parameters). Treatment of MYR was increased in GSH,GPx,CAT,SOD activity while TBARS level was decreased. In addition, degenerative changes in I/R group heart tissue were ameliorated by MYR administration. CONCLUSION: The administration of beta-myrcene protects oxidative and histological damage in the heart tissue after global ischemia-reperfusion and may be useful safe alternative treatment for cardiac tissue after ischemic stroke.en_US
dc.identifier.doi10.1590/S0102-865020160070000005
dc.identifier.endpage462en_US
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue7en_US
dc.identifier.pmid27487280en_US
dc.identifier.scopus2-s2.0-84979771551en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage456en_US
dc.identifier.urihttps://doi.org/10.1590/S0102-865020160070000005
dc.identifier.urihttps://hdl.handle.net/11616/97445
dc.identifier.volume31en_US
dc.identifier.wosWOS:000380801700005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherActa Cirurgica Brasileiraen_US
dc.relation.ispartofActa Cirurgica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBrain Ischemiaen_US
dc.subjectReperfusionen_US
dc.subjectOxidative Stressen_US
dc.subjectMiceen_US
dc.titleThe protective cardiac effects of B-myrcene after global cerebral ischemia/reperfusion in C57BL/J6 mouseen_US
dc.typeArticleen_US

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