Cuscuta arvensis Beyr Dodder: In Vivo Hepatoprotective Effects Against Acetaminophen-Induced Hepatotoxicity in Rats

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dc.authoridcaliskan, ufuk koca/0000-0002-5216-7588
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoriddonmez, ceylan/0000-0002-8005-4425;
dc.authorwosidcaliskan, ufuk koca/HIU-0019-2022
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosiddonmez, ceylan/JBS-3961-2023
dc.authorwosidTaşlıdere, Aslı/ABI-8274-2020
dc.contributor.authorKoca-Caliskan, Ufuk
dc.contributor.authorYilmaz, Ismet
dc.contributor.authorTaslidere, Asli
dc.contributor.authorYalcin, Funda N.
dc.contributor.authorAka, Ceylan
dc.contributor.authorSekeroglu, Nazim
dc.date.accessioned2024-08-04T20:44:35Z
dc.date.available2024-08-04T20:44:35Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCuscuta arvensis Beyr. is a parasitic plant, and commonly known as dodder in Europe, in the United States, and tu si zi shu in China. It is one of the preferred spices used in sweet and savory dishes. Also, it is used as a folk medicine for the treatment particularly of liver problems, knee pains, and physiological hepatitis, which occur notably in newborns and their mothers in the southeastern part of Turkey. The purpose of this study was to investigate the hepatoprotective effects and antioxidant activities of aqueous and methanolic extracts of C. arvensis Beyr. on acetaminophen (APAP)-induced acute hepatotoxicity in rats. The results were supported by subsequent histopathological studies. The hepatoprotective activity of both the aqueous and methanolic extracts at an oral dose of 125 and 250mg/kg was investigated by observing the reduction levels or the activity of alkaline phosphatase, alkaline transaminase, aspartate aminotransferase, blood urine nitrogen, and total bilirubin content. In vivo antioxidant activity was determined by analyzing the serum superoxide dismutase, malondialdehyde, glutathione, and catalase levels. Chromatographic methods were used to isolate biologically active compounds from the extract, and spectroscopic methods were used for structure elucidation. Both the methanolic and aqueous extracts exerted noticable hepatoprotective and antioxidant effects supporting the folkloric usage of dodder. One of the bioactive compounds was kaempferol-3-O-rhamnoside, isolated and identified from the methanolic extract.en_US
dc.description.sponsorshipGazi University Scientific Research Projects Unit [02/2012-03]en_US
dc.description.sponsorshipThe authors express genuine thanks for the financial support provided by the Gazi University Scientific Research Projects Unit, with the project number 02/2012-03.en_US
dc.identifier.doi10.1089/jmf.2017.0139
dc.identifier.endpage631en_US
dc.identifier.issn1096-620X
dc.identifier.issn1557-7600
dc.identifier.issue6en_US
dc.identifier.pmid29719159en_US
dc.identifier.scopus2-s2.0-85048680150en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage625en_US
dc.identifier.urihttps://doi.org/10.1089/jmf.2017.0139
dc.identifier.urihttps://hdl.handle.net/11616/98344
dc.identifier.volume21en_US
dc.identifier.wosWOS:000431370000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofJournal of Medicinal Fooden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectacetaminophenen_US
dc.subjectCuscutaen_US
dc.subjecthepatoprotectiveen_US
dc.subjecthistopathologyen_US
dc.subjectin vivo antioxidant activityen_US
dc.titleCuscuta arvensis Beyr Dodder: In Vivo Hepatoprotective Effects Against Acetaminophen-Induced Hepatotoxicity in Ratsen_US
dc.typeArticleen_US

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