Inhibitory effect of caffeic acid phenethyl ester on bleomycine-induced lung fibrosis in rats

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dc.authoridOZYURT, Huseyin/0000-0003-2327-4082
dc.authoridArmutcu, Ferah/0000-0002-3218-9480
dc.authorwosidOZYURT, Huseyin/N-4351-2015
dc.authorwosidArmutcu, Ferah/A-1364-2019
dc.contributor.authorÖzyurt, H
dc.contributor.authorSögüt, S
dc.contributor.authorYildirim, Z
dc.contributor.authorKart, L
dc.contributor.authorIraz, M
dc.contributor.authorArmutçu, F
dc.contributor.authorTemel, I
dc.date.accessioned2024-08-04T20:13:39Z
dc.date.available2024-08-04T20:13:39Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Pulmonary fibrosis (PF) induced by anticancerogenic bleomycin (BLM) is one of the more common side effects encountered during cancer treatment. It has been suggested in the last decades that the main responsible agent in PF is reactive oxygen species which were generated also in normal physiological conditions in the human body. In this experimental study, we investigated the preventive or attenuating effects of caffeic acid phenethyl ester (CAPE) that has been demonstrated to have anti-inflammatory, cytocytatic, anti cancerogenic, antiprolipherative and antioxidant effects on BLM-induced PF. Methods: Thirty-six Sprague-Dawley rats were divided randomly into four groups as sham operation, BLM, BLM + vitamin E (vit E), and BLM + CAPE groups. BLM (7.5 mg/kg, single dose) was applied intratracheally, and CAPE and vit E intraperitoneally in the appropriate groups. At the end of the fibrosis processes, lung tissues were removed and the levels of tissues hydroxyproline (OH-proline), malondialdehyde (MDA) and NO as well as the activities of superoxide dismutase (SOD), catalase (CAT) and myeloperoxidase (MPO) were determined. Also, the weights of the rats were recorded at 7th and 14th days of the experiments. Results: BLM application to the rats resulted in a significant increase in the OH-proline level as compared to the controls. Administration of CAPE and vit E led to the remarkable reduction of total lung OH-proline levels compared to the rats treated with BLM alone (p < 0.0001). There were a decreases in antioxidant enzyme (SOD and CAT) activities while an increase in MPO activity in BLM group was found vs. the control group (p < 0.0001). CAPE had a regulator effect on these parameters: the increase in CAT and SOD activities and the decrease in MPO activity were seen after CAPE application. NO, MDA and OH-proline levels were increased in BLM group vs. the control group. CAPE was more effective in decreasing the tissue levels of NO, MDA and OH-proline than vit E. MPO activity, as a good marker of neutrophil sequestration to the tissues, in the BLM group was decreased by CAPE approximately to the control group. Conclusion: We suggest that CAPE is more effective on the prevention of BLM-induced fibrosis via antioxidant and free radical scavenger properties than vit E at the doses used in the present study. CAPE has some attenuating effects on BLM-induced PF affecting both oxidant and antioxidant systems as well as neutrophils sequestration. (C) 2003 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.cccn.2003.09.015
dc.identifier.endpage75en_US
dc.identifier.issn0009-8981
dc.identifier.issn1873-3492
dc.identifier.issue1-2en_US
dc.identifier.pmid14687895en_US
dc.identifier.scopus2-s2.0-10744221529en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage65en_US
dc.identifier.urihttps://doi.org/10.1016/j.cccn.2003.09.015
dc.identifier.urihttps://hdl.handle.net/11616/93764
dc.identifier.volume339en_US
dc.identifier.wosWOS:000188214900008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofClinica Chimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbicomycinen_US
dc.subjectlungen_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.subjectvitamin Een_US
dc.subjectantioxidantsen_US
dc.subjectlipid peroxidationen_US
dc.titleInhibitory effect of caffeic acid phenethyl ester on bleomycine-induced lung fibrosis in ratsen_US
dc.typeArticleen_US

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