Antioxidant Effect of Ethanolic Extract of Propolis in Liver of L-NAME Treated Rats

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dc.authoridGulhan, Mehmet Fuat/0000-0003-4838-1597
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authoridSelamoglu, Zeliha/0000-0001-9056-6435
dc.authorwosidGulhan, Mehmet Fuat/ABF-6804-2021
dc.authorwosidÖzdemir, İlknur/AAA-6216-2021
dc.contributor.authorSelamoglu, Zeliha S.
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorCiftci, Osman
dc.contributor.authorGulhan, Mehmet F.
dc.contributor.authorSavci, Ahmet
dc.date.accessioned2024-08-04T20:40:17Z
dc.date.available2024-08-04T20:40:17Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. The blocking of nitric oxide synthase (NOS) activity may cause vasoconstriction with formation of reactive oxygen species. Propolis is a natural product collected from plants by honeybees. Propolis has biological and pharmacological properties. Objectives. This study was designed to investigate the effects of propolis on catalase (CAT) activity, nitric oxide (NO) and malondialdehyde (MDA) levels in the liver tissues of NOS inhibited rats by N omega-Nitro-L-arginine methyl ester (L-NAME). Material and Methods. Rats were given a NOS inhibitor (L-NAME, 40 mg/kg, intraperitoneally) for 15 days to provoke hypertension and propolis (200 mg/kg, by gavage) the last 5 of the 15 days. Results. Nitric oxide levels in the liver tissue of the rats given L-NAME significantly decreased (p < 0.01). That parameter did not significantly alter in the liver of rats treated with propolis compared to the control group. CAT activity and MDA levels in the liver of the rats administrated L-NAME significantly increased compared to the control group (p < 0.01). These parameters significantly decreased in the liver of the rats given L-NAME + propolis compared to the L-NAME group (p < 0.01). Conclusions. The present data shows that L-NAME in the liver may enhance oxidative stress via inhibited nitric oxide synthase. Our results also suggest that this effect is suppressed by the antioxidant properties of propolis in the liver tissue of NOS inhibited ratsen_US
dc.description.sponsorshipNigde University Research Fund [BAP 2008/25]en_US
dc.description.sponsorshipThe Nigde University Research Fund (BAP 2008/25) is gratefully acknowledged for supporting this work.en_US
dc.identifier.endpage232en_US
dc.identifier.issn1899-5276
dc.identifier.issn2451-2680
dc.identifier.issue2en_US
dc.identifier.pmid25931353en_US
dc.identifier.scopus2-s2.0-84930441690en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage227en_US
dc.identifier.urihttps://hdl.handle.net/11616/96809
dc.identifier.volume24en_US
dc.identifier.wosWOS:000355532300006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWroclaw Medical Univen_US
dc.relation.ispartofAdvances in Clinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectL-NAMEen_US
dc.subjectliveren_US
dc.subjectoxidative stressen_US
dc.subjectpropolisen_US
dc.subjectraten_US
dc.titleAntioxidant Effect of Ethanolic Extract of Propolis in Liver of L-NAME Treated Ratsen_US
dc.typeArticleen_US

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