Comparing the regenerative effects of silymarin and apricot on liver regeneration after partial hepatectomy in rats

dc.authorscopusid7004914053
dc.authorscopusid24376209000
dc.authorscopusid55623262400
dc.authorscopusid57209542162
dc.contributor.authorYilmaz İ.
dc.contributor.authorHatipoğlu H.S.
dc.contributor.authorTaşlidere E.
dc.contributor.authorKaraaslan M.
dc.date.accessioned2024-08-04T19:59:38Z
dc.date.available2024-08-04T19:59:38Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study is aimed to investigate and compare the regenerative effects of Silymarin (SLM); and Sun Dried Organic Apricot (SDOA) on liver regeneration after 70% Partial Hepatectomy (PH) in rats. Rats mean weighing was 238.1 ± 17.8 g, and they were randomly divided into the five groups. During the 17 d of the study period, the following feed and drug administration order was maintained: group 1 (sham) (n=6) and group 2 (n=8) were fed with standard rat chow, group 3 (n=8) was fed with standard rat chow and given additionally daily 100 mg/kg dose of silymarin extract by gavage, group 4 (n=8) was fed with 10% supplemented SDOA to chow and, in addition, they were given daily 100 mg/kg dose silymarin extract by gavage, and group 5 (n=8) was fed with 10% supplemented SDOA to chow. Water was given ad-libitum to all groups. After a week, group 1 had a laparoscopic procedure; the others underwent a 70% PH. On 18th d of the study, all rats were humanely sacrificed. Taken liver tissue samples of all groups were used to histopathological and tissue biochemical examination. Approximately 10 ml blood samples were taken and the obtained serum samples were used for measurement of serum Aspartate Transaminase (AST) AST, Alanine Transaminase (ALT) and Alkaline Phosphatase (ALP) levels. The results of the present study revealed a remarkable protective effect of silymarin rather than SDOA based on the histopathological and Proliferating Cell Nuclear Antigen, (PCNA). PCNA findings and liver tissue/serum biochemical parameters. Therefore, before 7 and after 10 d of PH, silymarin administration have shown beneficial effect than SDOA consumption on liver regeneration of rats. © 2018, Scientific Publishers of India. All rights reserved.en_US
dc.description.sponsorship2014/28; Inönü Üniversitesien_US
dc.description.sponsorshipThis study was supported by the Scientific Research Fund of Inonu University (Project number: (2014/28). The authors would like to express profound thanks for the financial support to the Unit of Scientific Research Projects of Inonu University. Additionally, we would like to thank Associate Prof. Dr. Turan ARABACI, Inonu University Pharmacy Faculty and Department of Pharmaceutical Botany for the botanical supports he provided.en_US
dc.identifier.doi10.4066/biomedicalresearch.29-17-2142
dc.identifier.endpage1473en_US
dc.identifier.issn0970-938X
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-85047161972en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1465en_US
dc.identifier.urihttps://doi.org/10.4066/biomedicalresearch.29-17-2142
dc.identifier.urihttps://hdl.handle.net/11616/90764
dc.identifier.volume29en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherScientific Publishers of Indiaen_US
dc.relation.ispartofBiomedical Research (India)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApricoten_US
dc.subjectLiver regenerationen_US
dc.subjectPartial hepatectomyen_US
dc.subjectRaten_US
dc.subjectSilymarinen_US
dc.titleComparing the regenerative effects of silymarin and apricot on liver regeneration after partial hepatectomy in ratsen_US
dc.typeArticleen_US

Dosyalar