Comparing the regenerative effects of silymarin and apricot on liver regeneration after partial hepatectomy in rats
dc.authorscopusid | 7004914053 | |
dc.authorscopusid | 24376209000 | |
dc.authorscopusid | 55623262400 | |
dc.authorscopusid | 57209542162 | |
dc.contributor.author | Yilmaz İ. | |
dc.contributor.author | Hatipoğlu H.S. | |
dc.contributor.author | Taşlidere E. | |
dc.contributor.author | Karaaslan M. | |
dc.date.accessioned | 2024-08-04T19:59:38Z | |
dc.date.available | 2024-08-04T19:59:38Z | |
dc.date.issued | 2018 | |
dc.department | İnönü Üniversitesi | en_US |
dc.description.abstract | This study is aimed to investigate and compare the regenerative effects of Silymarin (SLM); and Sun Dried Organic Apricot (SDOA) on liver regeneration after 70% Partial Hepatectomy (PH) in rats. Rats mean weighing was 238.1 ± 17.8 g, and they were randomly divided into the five groups. During the 17 d of the study period, the following feed and drug administration order was maintained: group 1 (sham) (n=6) and group 2 (n=8) were fed with standard rat chow, group 3 (n=8) was fed with standard rat chow and given additionally daily 100 mg/kg dose of silymarin extract by gavage, group 4 (n=8) was fed with 10% supplemented SDOA to chow and, in addition, they were given daily 100 mg/kg dose silymarin extract by gavage, and group 5 (n=8) was fed with 10% supplemented SDOA to chow. Water was given ad-libitum to all groups. After a week, group 1 had a laparoscopic procedure; the others underwent a 70% PH. On 18th d of the study, all rats were humanely sacrificed. Taken liver tissue samples of all groups were used to histopathological and tissue biochemical examination. Approximately 10 ml blood samples were taken and the obtained serum samples were used for measurement of serum Aspartate Transaminase (AST) AST, Alanine Transaminase (ALT) and Alkaline Phosphatase (ALP) levels. The results of the present study revealed a remarkable protective effect of silymarin rather than SDOA based on the histopathological and Proliferating Cell Nuclear Antigen, (PCNA). PCNA findings and liver tissue/serum biochemical parameters. Therefore, before 7 and after 10 d of PH, silymarin administration have shown beneficial effect than SDOA consumption on liver regeneration of rats. © 2018, Scientific Publishers of India. All rights reserved. | en_US |
dc.description.sponsorship | 2014/28; Inönü Üniversitesi | en_US |
dc.description.sponsorship | This study was supported by the Scientific Research Fund of Inonu University (Project number: (2014/28). The authors would like to express profound thanks for the financial support to the Unit of Scientific Research Projects of Inonu University. Additionally, we would like to thank Associate Prof. Dr. Turan ARABACI, Inonu University Pharmacy Faculty and Department of Pharmaceutical Botany for the botanical supports he provided. | en_US |
dc.identifier.doi | 10.4066/biomedicalresearch.29-17-2142 | |
dc.identifier.endpage | 1473 | en_US |
dc.identifier.issn | 0970-938X | |
dc.identifier.issue | 7 | en_US |
dc.identifier.scopus | 2-s2.0-85047161972 | en_US |
dc.identifier.scopusquality | N/A | en_US |
dc.identifier.startpage | 1465 | en_US |
dc.identifier.uri | https://doi.org/10.4066/biomedicalresearch.29-17-2142 | |
dc.identifier.uri | https://hdl.handle.net/11616/90764 | |
dc.identifier.volume | 29 | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.language.iso | en | en_US |
dc.publisher | Scientific Publishers of India | en_US |
dc.relation.ispartof | Biomedical Research (India) | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Apricot | en_US |
dc.subject | Liver regeneration | en_US |
dc.subject | Partial hepatectomy | en_US |
dc.subject | Rat | en_US |
dc.subject | Silymarin | en_US |
dc.title | Comparing the regenerative effects of silymarin and apricot on liver regeneration after partial hepatectomy in rats | en_US |
dc.type | Article | en_US |