Histopathological Effects of Teriparatide in Medication-Related Osteonecrosis of the Jaw: An Animal Study

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dc.authoridBozdag, Zehra/0000-0002-0477-2513
dc.authoridYolcu, Ümit/0000-0001-7312-2867
dc.authoridARAS, Mutan/0000-0002-8907-7340
dc.authorwosidBozdag, Zehra/AAG-5279-2020
dc.authorwosidYolcu, Ümit/ABH-6916-2020
dc.contributor.authorKeskinruzgar, Aydin
dc.contributor.authorBozdag, Zehra
dc.contributor.authorAras, Mutan Hamdi
dc.contributor.authorDemir, Tuncer
dc.contributor.authorYolcu, Umit
dc.contributor.authorCetiner, Sedat
dc.date.accessioned2024-08-04T20:41:28Z
dc.date.available2024-08-04T20:41:28Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: Osteonecrosis of the jaw after tooth extraction is a major complication in patients using bisphosphonates (BPs) for bone lesions, such as for the treatment of osteoporosis. The purpose of this study was to investigate the histopathologic effects of teriparatide (a synthetic parathyroid hormone) on rats developing osteonecrosis with BP use. Materials and Methods: Rats (n = 80) that had been injected intraperitoneally with zoledronic acid for 7 weeks were used. Maxillary first molar extractions and bone defects were established in the same region in the eighth week. Teriparatidewas administered subcutaneously to prevent osteonecrosis. Animals were sacrificed and histopathologic changes were examined. Osteoblasts, osteoclasts, inflammatory phase of bone healing, and osteonecrotic areas were evaluated. Results: The osteoclast numbers were larger in the experimental groups (teriparatide administered before and immediately after tooth extraction) than in the control group (administered zoledronic acid). The inflammatory phase of bone healing was more pronounced in the experimental group (teriparatide administered before tooth extraction) than in the control group. There were significant differences in osteoclast numbers and in the inflammatory phase of bone healing between the experimental and control groups (P < .05). The osteoblast numbers and osteonecrotic areas were similar in size between the experimental and control groups. There were no significant differences (P > .05). Conclusions: BPs have negative effects on osteoclasts and the inflammatory phase of bone healing, whereas teriparatide was found to be effective in eliminating the negative effects of BPs. Teriparatide had positive effects in preventing osteonecrosis; therefore, teriparatide could be an effective agent for MRONJ. (C) 2016 American Association of Oral and Maxillofacial Surgeonsen_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [111S454]en_US
dc.description.sponsorshipThis research was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) (Project grant number; 111S454).en_US
dc.identifier.doi10.1016/j.joms.2015.07.005
dc.identifier.endpage78en_US
dc.identifier.issn0278-2391
dc.identifier.issn1531-5053
dc.identifier.issue1en_US
dc.identifier.pmid26215490en_US
dc.identifier.scopus2-s2.0-84955708209en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage68en_US
dc.identifier.urihttps://doi.org/10.1016/j.joms.2015.07.005
dc.identifier.urihttps://hdl.handle.net/11616/97143
dc.identifier.volume74en_US
dc.identifier.wosWOS:000367357900011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal of Oral and Maxillofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBisphosphonate-Related Osteonecrosisen_US
dc.subjectTooth Extractionen_US
dc.subjectBoneen_US
dc.subjectZoledronateen_US
dc.subjectAlendronateen_US
dc.subjectOsteoprotegerinen_US
dc.subjectMechanismsen_US
dc.subjectResolutionen_US
dc.subjectRanklen_US
dc.titleHistopathological Effects of Teriparatide in Medication-Related Osteonecrosis of the Jaw: An Animal Studyen_US
dc.typeArticleen_US

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