Contribution of adrenomedullin to homeostatic response to cold stress in rat model

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dc.authorscopusid12797912000
dc.authorscopusid6701438855
dc.authorscopusid6602072091
dc.contributor.authorYüksel Ş.
dc.contributor.authorAkbay A.
dc.contributor.authorYürekli M.
dc.date.accessioned2024-08-04T19:59:33Z
dc.date.available2024-08-04T19:59:33Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAcute stress known to stimulate sympathetic activity as well as the hypothalamo-pituitary-adrenal (HPA) axis, produces a significant increase in adrenomedullin (ADM) levels in the pituitary gland, plasma and adrenal glands, all of which are key components of HPA axis, suggesting a regulatory or protective role for ADM in countering HPA activation following a variety of physiological and psychological stressors. This study was conducted to assess a rat model for in depth investigation of biochemical mechanisms and consequences of cold stress. Four groups of Sprague-Dawley rats were observed for their serum total protein, glucose, trigliceride and cholesterol levels as well as their blood pressures after housing at room temperature, administration of ADM (1.0 nm/kg), exposing to cold stress (8°C for 48 h) and exposing to ADM injection in addition to cold stress. The results suggest that application of ADM in addition to cold stress may act via receptors on different end-organs and causes altered metabolic regulation taking partial or total occupation of ADM receptors, stimulated in response to cold application induced physiologic ADM release before pharmacological ADM administration. © 2002 Elsevier Science Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/S0928-4680(02)00016-0
dc.identifier.endpage247en_US
dc.identifier.issn0928-4680
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-0036288572en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage243en_US
dc.identifier.urihttps://doi.org/10.1016/S0928-4680(02)00016-0
dc.identifier.urihttps://hdl.handle.net/11616/90726
dc.identifier.volume8en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofPathophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdrenomedullinen_US
dc.subjectBlood pressureen_US
dc.subjectCold stressen_US
dc.subjectMetabolicen_US
dc.subjectRaten_US
dc.subjectStressen_US
dc.titleContribution of adrenomedullin to homeostatic response to cold stress in rat modelen_US
dc.typeArticleen_US

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