Silver and ruthenium complexes with anthracene functionalized N-heterocyclic carbene ligands: catalytic and cytotoxicity properties

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dc.authoridÖzdemir, Namık/0000-0003-3371-9874
dc.authoridKeleştemur, Ünzile/0000-0003-4531-6378
dc.authorwosidÖzdemir, Namık/J-6434-2015
dc.authorwosidKeleştemur, Ünzile/A-4190-2018
dc.contributor.authorKaratas, Mert Olgun
dc.contributor.authorKelestemur, Unzile
dc.contributor.authorMumcu, Akin
dc.contributor.authorOzdemir, Namik
dc.contributor.authorErdogan, Ali
dc.contributor.authorKucukbay, Hasan
dc.date.accessioned2024-08-04T20:56:07Z
dc.date.available2024-08-04T20:56:07Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, we have synthesized two Ag (2a and 2b) and two Ru (3a and 3b) complexes with anthracene substituted N-heterocyclic carbene (NHC) ligands. Ag-NHC complexes have been synthesized by the interaction of corresponding benzimidazolium chloride and Ag2O. Ru-NHC complexes have been synthesized by the transmetalation reaction between corresponding Ag-NHC and [RuCl2(p-cymene)]2 dimer. The synthesized complexes have been characterized by elemental analysis, NMR (1H and 13C NMR), and mass (high resolution mass spectroscopy, HRMS) spectroscopic techniques. In order to assess the catalytic potential of the Ru-NHC complexes, we have conducted experiments involving the hydrosilylation of terminal alkynes. Both complexes have exhibited a moderate level of catalytic activity, achieving conversions ranging from 70 to 90%, along with a substantial beta-(Z) selectivity within the range of 80-90%. Furthermore, we have also subjected the benzimidazolium chlorides (1a and 1b), Ag-NHCs and Ru-NHCs to cytotoxicity testing using human breast cancer cells (MCF-7) and human colorectal cancer cells (Caco-2). The results of these assays have demonstrated that all compounds strongly inhibit the proliferation of both cell lines.en_US
dc.identifier.doi10.1007/s11243-024-00590-x
dc.identifier.issn0340-4285
dc.identifier.issn1572-901X
dc.identifier.scopus2-s2.0-85196703849en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s11243-024-00590-x
dc.identifier.urihttps://hdl.handle.net/11616/102074
dc.identifier.wosWOS:001253681500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofTransition Metal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTerminal Alkynesen_US
dc.subjectMetal-Complexesen_US
dc.subjectHydrosilylationen_US
dc.subjectAlkylationen_US
dc.subjectAg(I)en_US
dc.subjectDnaen_US
dc.titleSilver and ruthenium complexes with anthracene functionalized N-heterocyclic carbene ligands: catalytic and cytotoxicity propertiesen_US
dc.typeArticleen_US

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