Novel N-heterocyclic carbene silver(I) complexes: Synthesis, structural characterization, and anticancer activity

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dc.authoridŞAHİN-BÖLÜKBAŞI, Serap/0000-0003-1057-2558
dc.authoridÖzdemir, İsmail/0000-0001-6325-0216
dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authoridTahir, Muhammad Nawaz/0000-0002-6815-9806;
dc.authorwosidŞAHİN-BÖLÜKBAŞI, Serap/ABJ-7836-2022
dc.authorwosidÖzdemir, İsmail/ABI-5192-2020
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.authorwosidTahir, Muhammad Nawaz/HPB-5726-2023
dc.authorwosidŞAHİN, Neslihan/F-6402-2019
dc.contributor.authorBolukbasi, Serap Sahin
dc.contributor.authorSahin, Neslihan
dc.contributor.authorTahir, Muhammad Nawaz F.
dc.contributor.authorArici, Cengiz
dc.contributor.authorCevik, Esranur
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorOzdemir, Ismail
dc.date.accessioned2024-08-04T20:45:33Z
dc.date.available2024-08-04T20:45:33Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, we synthesized four novel unsymmetrically substituted NHC ligands (la-d) and their Ag(I) complexes (2a-d). All new compounds were characterized using elemental analysis, FT-IR, H-1 NMR, and C-13 NMR spectroscopy and X-ray crystallography. The molecular structure of complex 2d was elucidated through single crystal X-ray diffraction analyses. Single crystal structural studies for complex 2d show that the benzene rings (C9-C14) and the central benzimidazole ring system make dihedral angles of 85.65(11)degrees. The Ag-Cl and Ag-C single bond lengths are 2.3553(7) and 2.096(2)angstrom, respectively. The C-Ag-C/ bond angle is 168.27(7)degrees. Both salts and complexes were tested for their anti-cancer potential against three human cancer cell lines (DU-145, MCF-7, and MDA-MB-231) and non-cancer cells adipose from mouse (L-929) for 24 h, 48 h and 72 h using the MTT assays. However, the Ag(I)-NHC complexes (2a-d) showed a dose and time-dependent cytotoxic activity against all cell lines. MDA-MB-231 human breast carcinoma cells were the most sensitive to the Ag(I)-NHC complex displaying IC50 lower than 1 mu M all time points. Further, the IC(50)s for Ag(I)-NHC were higher in non-cancer cells, suggesting that complexes possessed noteworthy selectivity for human cancer cells.en_US
dc.description.sponsorshipScientific and Technological Research of Turkey (TUBITAK-BIDEB); National Research Fellow-ship Programme; National Institutes of Health (NIH); National Institute of Biomedical Imaging and Bioengineering NIBIB [EB0160100]; Department of Defense Prostate Cancer Research Program Idea Development Award [PC150431 GRANT11996600]en_US
dc.description.sponsorshipThe authors thank the Scientific and Technological Research of Turkey (TUBITAK-BIDEB), the National Research Fellow-ship Programme for grants to N. S. This project was supported in part with funds from the National Institutes of Health (NIH); National Institute of Biomedical Imaging and Bioengineering NIBIB (EB0160100 to B.S.C.) and a Department of Defense Prostate Cancer Research Program Idea Development Award (PC150431 GRANT11996600) to B.S.C.en_US
dc.identifier.doi10.1016/j.ica.2018.11.044
dc.identifier.endpage718en_US
dc.identifier.issn0020-1693
dc.identifier.issn1873-3255
dc.identifier.scopus2-s2.0-85057564159en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage711en_US
dc.identifier.urihttps://doi.org/10.1016/j.ica.2018.11.044
dc.identifier.urihttps://hdl.handle.net/11616/98554
dc.identifier.volume486en_US
dc.identifier.wosWOS:000454151300091en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofInorganica Chimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectSilver complexen_US
dc.subjectBenzimidazole-2-ylideneen_US
dc.subjectAnticancer activityen_US
dc.titleNovel N-heterocyclic carbene silver(I) complexes: Synthesis, structural characterization, and anticancer activityen_US
dc.typeArticleen_US

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