Role of caffeic acid phenethyl ester, an active component of propolis, against cisplatin-induced nephrotoxicity in rats

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dc.authoridOZYURT, Huseyin/0000-0003-2327-4082
dc.authorwosidOZYURT, Huseyin/N-4351-2015
dc.contributor.authorÖzen, S
dc.contributor.authorAkyol, Ö
dc.contributor.authorIraz, M
dc.contributor.authorSögüt, S
dc.contributor.authorÖzugurlu, F
dc.contributor.authorÖzyurt, H
dc.contributor.authorOdaci, E
dc.date.accessioned2024-08-04T20:13:37Z
dc.date.available2024-08-04T20:13:37Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe have investigated the effect of caffeic acid phenethyl ester (CAPE) on cisplatin-induced nephrotoxicity in rats. Administration of a single dose of cisplatin resulted in the elevation of blood area nitrogen and creatinine in serum, as well as nitric oxide in kidney tissue of rats. Cisplatin also caused reduction of catalase (P < 0.0001), superoxide dismutase (P = 0.149) and glutathrone peroxidase (P < 0.0001) activities in kidney tissue. Although cisplatin caused elevation in malondialdehyde levels and myeloperoxidase activities in kidney tissue, they were not statistically significant. Caffeic acid phenethyl ester was found to be protective against cisplatin-induced antioxidant enzyme reductions. Treatment with free-radical scavenger CAPE attenuated the increase in plasma blood area nitrogen and kidney nitric oxide levels, and showed histopathological protection against cisplatin-induced acute renal failure. Extensive epithelial cell vacuolization, swelling, desquamation and necrosis were observed in the kidney of the cisplatin-treated rat. There were also larger tubular lumens in cisplatin-treated rats than those of the control and the CAPE groups. Caffeic acid phenethyl ester caused a marked reduction in the extent of tubular damage. It is concluded that administration of cisplatin imposes an oxidative stress to renal tissue and CAPE confers protection against the oxidative damage associated with cisplatin. This mechanism may be attributed to its free-oxygen-radical scavenging activity. Copyright (C) 2004 John Wiley Sons, Ltd.en_US
dc.identifier.doi10.1002/jat.941
dc.identifier.endpage35en_US
dc.identifier.issn0260-437X
dc.identifier.issn1099-1263
dc.identifier.issue1en_US
dc.identifier.pmid14745844en_US
dc.identifier.scopus2-s2.0-0442326350en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://doi.org/10.1002/jat.941
dc.identifier.urihttps://hdl.handle.net/11616/93731
dc.identifier.volume24en_US
dc.identifier.wosWOS:000188501100005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Applied Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.subjectcisplatinen_US
dc.subjectnephrotoxicityen_US
dc.subjectnitric oxideen_US
dc.subjectcatalaseen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectglutathione peroxidaseen_US
dc.subjectmalondialdehydeen_US
dc.subjectmyeloperoxidaseen_US
dc.titleRole of caffeic acid phenethyl ester, an active component of propolis, against cisplatin-induced nephrotoxicity in ratsen_US
dc.typeArticleen_US

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