Plasma lipid peroxidation products and antioxidant enzyme activities in patients with type 2 diabetes mellitus

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dc.authoridSevinç, Alper/0000-0002-0499-8918;
dc.authorwosidSevinç, Alper/KPA-4519-2024
dc.authorwosidCamci, Celaletdin/AAD-1910-2019
dc.authorwosidSevinc, Alper/KFQ-6440-2024
dc.contributor.authorTurk, HM
dc.contributor.authorSevinc, A
dc.contributor.authorCamci, C
dc.contributor.authorCigli, A
dc.contributor.authorBuyukberber, S
dc.contributor.authorSavli, H
dc.contributor.authorBayraktar, N
dc.date.accessioned2024-08-04T20:13:09Z
dc.date.available2024-08-04T20:13:09Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractDiabetes is associated with a significant increase in thiobarbituric acid reactive substances (TBARS) which are considered as an index of endogenous lipid peroxidation. The human body has a complex antioxidant defense system that prevents the initiation of free radical chain reactions. We measured plasma TBARS levels, superoxide dismutase (SOD) and catalase (CAT) activities and compared their relation to the metabolic control of diabetes and diabetic microangiopathy. Sixty-four patients (19 men), aged 52.35 +/- 9.31 years with type 2 diabetes mellitus were included in the study. Thirty-six healthy subjects (12 men), aged 51.02 +/- 7.01 years formed the control group. TBARS levels and SOD activity were elevated in the diabetic group when compared with the control group (p<0.001 and p<0.00001, respectively). However CAT activity was significantly decreased in the diabetic group when compared with the control group (p<0.00001). Patients with diabetic nephropathy and retinopathy. but not neuropathy, had elevated TBARS levels but there was no statistically significant difference when compared with diabetic patients without microangiopathy (p>0.05). There was a positive correlation between plasma TBARS levels and SOD activity (r=0.770, p=0.0001) and a negative correlation between plasma TBARS levels and CAT activity (r=-0.482, p=0.0001). There was also a negative correlation between SOD and CAT activities (r=-0.609, p=0.0001). We found significantly elevated TBARS levels in diabetic patients. We did not observe any correlation between TBARS levels and blood glucose and HbA(1c) levels. Elevated TBARS levels and SOD activity and decreased CAT activity may be due to a compensation mechanism of the body.en_US
dc.identifier.doi10.1007/s005920200029
dc.identifier.endpage122en_US
dc.identifier.issn0940-5429
dc.identifier.issn1432-5233
dc.identifier.issue3en_US
dc.identifier.pmid12357295en_US
dc.identifier.scopus2-s2.0-0036744927en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage117en_US
dc.identifier.urihttps://doi.org/10.1007/s005920200029
dc.identifier.urihttps://hdl.handle.net/11616/93436
dc.identifier.volume39en_US
dc.identifier.wosWOS:000178633700003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer-Verlag Italia Srlen_US
dc.relation.ispartofActa Diabetologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectthiobarbituric acid reactive substancesen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectcatalaseen_US
dc.subjecttype 2 diabetes mellitusen_US
dc.titlePlasma lipid peroxidation products and antioxidant enzyme activities in patients with type 2 diabetes mellitusen_US
dc.typeArticleen_US

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