The importance of pulmonary pulse transit time in indicating right ventricular dysfunction and pulmonary arterial stiffness in rheumatoid arthritis

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dc.authoridKaraca, Yücel/0000-0002-5184-5308
dc.authoridHidayet, Siho/0000-0002-4103-9345
dc.authorwosidKaraca, Yücel/AAA-4477-2022
dc.authorwosidUlutaş, Zeynep/JMB-6092-2023
dc.contributor.authorUlutas, Zeynep
dc.contributor.authorTasolar, Hakan
dc.contributor.authorBayramoglu, Adil
dc.contributor.authorYigit, Yakup
dc.contributor.authorKuloglu, Huseyin Emre
dc.contributor.authorKaraca, Yucel
dc.contributor.authorYolbas, Servet
dc.date.accessioned2024-08-04T20:54:36Z
dc.date.available2024-08-04T20:54:36Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSubject Rheumatoid arthritis patients are at risk of developing cardiovascular disease such as right heart failure and pulmonary hypertension (PH). Arterial stiffness can be used to assess pulmonary hemodynamics. Noninvasive approaches can also be used to assess pulmonary hemodynamics. Recently, there have been reports that pulmonary pulse transit time (PPTT) may also be a useful measure. This study aims to examine the effects of pulmonary hemodynamic alterations on PPTT in RA patients.Methods Forty RA patients and 40 healthy controls were included in the study. Sociodemographic characteristics, laboratory data, and echocardiographic examinations were performed in both groups. Conventional echocardiographic examination included left and right ventricular systolic and diastolic diameters, right ventricular myocardial performance index (RVMPI), right ventricular diastolic function, estimated pulmonary artery systolic pressure (sPAP), tricuspid annular plane systolic excursion (TAPSE), pulmonary artery stiffness (PAS), and PPTT. Right ventricular diastolic and systolic volumes, right ventricular ejection fraction (RVEF), and right ventricular fractional area change (RVFAC) were determined by four-dimensional echocardiography (4DE).Results There was no difference between the sPAP values of the patients. RVMPI and PAS were increased in RA patients compared with controls. The PPTT was shortened in RA patients and correlated with RVEF, RVFAC, RVMPI, TAPSE/sPAP, disease duration, and C-reactive protein (CRP). In univariate linear regression analysis, PPTT (p < .001) was thought to be an independent predictor of PAS. RVFAC, disease duration, and PAS were also independent predictors of PPTT.Conclusion In RA patients, PPTT may be the first evidence of early abnormalities in pulmonary vascular hemodynamics. PPTT and PAS are the values that may predict each other in RA patients. Due to its more practical application, PPTT can be used instead of PAS to assess pulmonary hemodynamics.en_US
dc.identifier.doi10.1002/jcu.23531
dc.identifier.endpage1328en_US
dc.identifier.issn0091-2751
dc.identifier.issn1097-0096
dc.identifier.issue8en_US
dc.identifier.pmid37530482en_US
dc.identifier.scopus2-s2.0-85166653181en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1321en_US
dc.identifier.urihttps://doi.org/10.1002/jcu.23531
dc.identifier.urihttps://hdl.handle.net/11616/101500
dc.identifier.volume51en_US
dc.identifier.wosWOS:001041370300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Clinical Ultrasounden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectpulmonary arterial stiffnessen_US
dc.subjectpulmonary pulse transit timeen_US
dc.subjectrheumatoid arthritisen_US
dc.titleThe importance of pulmonary pulse transit time in indicating right ventricular dysfunction and pulmonary arterial stiffness in rheumatoid arthritisen_US
dc.typeArticleen_US

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