Can Blood Biomarkers Be Used to Assess Oxidative Stress in COPD Patients After Pulmonary Rehabilitation

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dc.authoridBeykumul, Aysegul/0000-0001-7835-2194
dc.contributor.authorBeykumul, Aysegul
dc.contributor.authorErsoy, Yuksel
dc.contributor.authorGulbas, Gazi
dc.contributor.authorNeselioglu, Salim
dc.date.accessioned2024-08-04T20:54:46Z
dc.date.available2024-08-04T20:54:46Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: To determine the level of oxidative stress in the body due to pulmonary rehabilitation (PR) with thiols and disulfide and to investigate their relationship with indirect markers such as creatine kinase (CK), creatine kinase - MB (CK-MB), and lactate dehydrogenase (LDH), which show cell destruction.Patients and Methods: Patients with chronic obstructive pulmonary disease (COPD) are included in inpatient and outpatient care. They were evaluated before and after for PR, and an exercise program was prescribed. In addition, native thiol (NT), total thiol (TT), disulfide (DS), LDH, CK, and CK-MB values were tested.Results: The mean age of 21 patients was 63 +/- 7.31 years. Eleven of them were outpatients and 10 of them were inpatients. Most of the patients were male (M/F=20/1, 95.2/4.8%). There was a significant difference in pulmonary function tests (PFT), St. George Respiratory Questionnaire (SGRQ), and 1 repetition maximum (1RM) before and after the treatment (p<0.001). There was a correlation between PFT and 1RM upper extremity. While there was no significant difference between thiols and disulfide, according to GOLD scores, there was a significant difference in patients with level 3-MMRC. No correlation was found between LDH, CK, CKMB, and thiols, DS. Delta CK was found to be associated with Delta DS, and Delta CK-MB with Delta NT, and Delta TT.Conclusion: PR contributes to the antioxidant process by improving respiration and reducing oxidative stress. The decrease in LDH, CK with PR, increase in CK-MB, and correlation of CK with thiols and DS gave a different interpretation. In this case, it should be considered that oxidative stress may also be increased in people with high CK values.en_US
dc.identifier.doi10.2147/COPD.S400415
dc.identifier.endpage2186en_US
dc.identifier.issn1178-2005
dc.identifier.pmid37818173en_US
dc.identifier.scopus2-s2.0-85174147573en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2179en_US
dc.identifier.urihttps://doi.org/10.2147/COPD.S400415
dc.identifier.urihttps://hdl.handle.net/11616/101624
dc.identifier.volume18en_US
dc.identifier.wosWOS:001084640600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofInternational Journal of Chronic Obstructive Pulmonary Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCKen_US
dc.subjectCK-MBen_US
dc.subjectCOPDen_US
dc.subjectLDHen_US
dc.subjectoxidative stressen_US
dc.subjectpulmonary rehabilitationen_US
dc.titleCan Blood Biomarkers Be Used to Assess Oxidative Stress in COPD Patients After Pulmonary Rehabilitationen_US
dc.typeArticleen_US

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