Germline cells in ovarian surface epithelium of mammalians: a promising notion

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dc.authoridCelik, ebru/0000-0002-0774-4294
dc.authoridTURKCUOGLU, ILGIN/0000-0002-8342-1956
dc.authorwosidCelik, ebru/X-4343-2019
dc.authorwosidSimsek, Yavuz/AAH-9894-2021
dc.contributor.authorCelik, Onder
dc.contributor.authorCelik, Ebru
dc.contributor.authorTurkcuoglu, Ilgin
dc.contributor.authorYilmaz, Ercan
dc.contributor.authorSimsek, Yavuz
dc.contributor.authorTiras, Bulent
dc.date.accessioned2024-08-04T20:36:15Z
dc.date.available2024-08-04T20:36:15Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIt is a long held doctrine in reproductive biology that women are born with a finite number of oocytes and there is no oogenesis during the postnatal period. However, recent evidence challenges this by showing the presence of germ line stem cells in the human ovarian surface epithelium (OSE), which can serve as a source of germ cells, and differentiate into oocyte like structures. Postnatal renewal of oocytes may have enormous therapeutic potential especially in women facing the risk of premature ovarian failure idiopathically or iatrogenically after exposure to gonadotoxic chemotherapy and radiation for cancer therapy. This article reviews current knowledge on germ line stem cells in human OSE.en_US
dc.identifier.doi10.1186/1477-7827-10-112
dc.identifier.issn1477-7827
dc.identifier.pmid23245287en_US
dc.identifier.scopus2-s2.0-84870995312en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1186/1477-7827-10-112
dc.identifier.urihttps://hdl.handle.net/11616/95884
dc.identifier.volume10en_US
dc.identifier.wosWOS:000314709100002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofReproductive Biology and Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHumanen_US
dc.subjectOvarian surface epitheliumen_US
dc.subjectStem cellsen_US
dc.subjectGerm line cellsen_US
dc.subjectPluripotencyen_US
dc.subjectOocyte-like cellsen_US
dc.titleGermline cells in ovarian surface epithelium of mammalians: a promising notionen_US
dc.typeReview Articleen_US

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