Evaluating the Effect of Resveratrol on the Healing of Extraction Sockets in Cyclosporine A-Treated Rats

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dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridYolcu, Ümit/0000-0001-7312-2867
dc.authoridOzcan Kucuk, Ayse/0000-0002-8289-8066
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidalan, hilal/ABH-9301-2020
dc.authorwosidYolcu, Ümit/ABH-6916-2020
dc.authorwosidküçük, Ayşe Özcan/ABA-2158-2020
dc.authorwosidKüçük, ayşe/GRJ-5515-2022
dc.contributor.authorOzcan-Kucuk, Ayse
dc.contributor.authorAlan, Hilal
dc.contributor.authorGul, Mehmet
dc.contributor.authorYolcu, Umit
dc.date.accessioned2024-08-04T20:44:26Z
dc.date.available2024-08-04T20:44:26Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: The objective of this study was to investigate the effects of resveratrol on alveolar socket healing after tooth extraction in normal and cyclosporin A (CsA)-treated rats. Materials and Methods: Seventy-two female Sprague-Dawley rats were separated into 4 groups of 18. Group 1 was injected with a placebo solution intraperitoneally. Group 2 was injected with resveratrol (10 mu mol/kg) intraperitoneally. Groups 3 and 4 were injected with CsA (10 mg/kg) subcutaneously for 8 days once daily before tooth extraction. Next, the teeth were extracted and CsA injection continued until the animals were sacrificed. Eight days after commencing the CsA injections, group 4 was injected with resveratrol while continuing with CsA injections. Nine rats from each group were sacrificed on days 14 and 28, and sections were examined to assess the degree of inflammation, formation of connective tissue, and new bone formation Immunohistochemical analysis was used to evaluate the alveolar socket healing process using osteocalcin and osteopontin markers. A P value less than .05 was considered significant. Results: There was more new bone formation in group 2 than in the other 3 groups on day 14 after tooth extraction (P < .05), and there was more new bone formation in group 2 than in groups 3 and 4 on day 28 after extraction (P < .05). Based on the immunohistochemical assessment, the amount of osteocalcin and osteopontin labeling was greater in group 2 compared with the other 3 groups on day 14 (P < .05); however, on day 28 after extraction, it was greater in group 4 compared with group 3 (P < .05). Conclusions: Resveratrol improves alveolar socket healing in normal and CsA-treated rats. Resveratrol also increases levels of osteocalcin and osteopontin in normal and CsA-treated rats. These results suggest that this natural compound is useful for alveolar socket healing after tooth extraction. (C) 2018 American Association of Oral and Maxillofacial Surgeonsen_US
dc.description.sponsorshipTUBITAK [214S260, 1002]en_US
dc.description.sponsorshipThis work was supported by TUBITAK through the Fast Support Program (1002; project number 214S260).en_US
dc.identifier.doi10.1016/j.joms.2018.02.030
dc.identifier.endpage1413en_US
dc.identifier.issn0278-2391
dc.identifier.issn1531-5053
dc.identifier.issue7en_US
dc.identifier.pmid29605535en_US
dc.identifier.scopus2-s2.0-85045571275en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1404en_US
dc.identifier.urihttps://doi.org/10.1016/j.joms.2018.02.030
dc.identifier.urihttps://hdl.handle.net/11616/98244
dc.identifier.volume76en_US
dc.identifier.wosWOS:000436415300006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal of Oral and Maxillofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMesenchymal Stem-Cellsen_US
dc.subjectTooth Extractionen_US
dc.subjectAlveolar Boneen_US
dc.subjectOsteoblastic Differentiationen_US
dc.subjectMatrix Metalloproteinasesen_US
dc.subjectDiabetic-Ratsen_US
dc.subjectProliferationen_US
dc.subjectTransplantationen_US
dc.subjectBioavailabilityen_US
dc.subjectOsteopontinen_US
dc.titleEvaluating the Effect of Resveratrol on the Healing of Extraction Sockets in Cyclosporine A-Treated Ratsen_US
dc.typeArticleen_US

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