The effects of total parenteral nutrition on telomerase expression in rabbit

dc.contributor.authorGürünlüoğlu, Kubilay
dc.contributor.authorBayrakci, Ercan
dc.contributor.authorKocabıyık, Alper
dc.contributor.authorGökçe, Hasan
dc.contributor.authorTaşkapan, Mehmet Çağatay
dc.contributor.authorTaşcı, Aytaç
dc.contributor.authorAksungur, Zeynep
dc.contributor.authorArslan, Ahmet Kadir
dc.contributor.authorDemircan, Mehmet
dc.date.accessioned2021-08-23T07:16:21Z
dc.date.available2021-08-23T07:16:21Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAbstract: Aim: Total parenteral nutrition (TPN) is a technique which is use to give vitally mandatory substances in to the venous compartments whenever the gastrointestinal system cannot be used by the patients. Telomerase catalyzes DNA synthesis, which is necessary to maintain telomere length and stabilize the genome to allow continued cell proliferation. In this study, we explored the effects of TPN administration on telomerase reverse transcriptase (TERT) expression in various tissue and serum telomerase level. Material and Methods: In this study a number of 42 same-aged albino, equal number of male and female, new zealand rabbits were use, divided in to three groups. Group 1 rabbits received TPN for 10 days via a central venous catheter. Group 2 received 50 mL/ kg/day physiological saline via a central venous catheter. Group 3 served as the control group. The rabbits were sacrificed after 10 days, and serum telomerase levels were measured by enzyme-linked immunosorbent assay. TERT expression in gonadal, liver, jejunum, and skin tissues were determined immunohistochemically. Blood samples were obtained before and after TPN and saline administration in the TPN and serum saline groups, respectively, and at the end of the experiment in the control group. Results: Telomerase expression in liver, gonads and serum level of TPN group was significantly higher than control and serum saline groups. Conclusion: TPN may be a positive effect in liver and gonadal telomer kinetic. However, we think that TPN increases DNA damage throughout the body.en_US
dc.identifier.doi10.5455/jtomc.2018.01.021en_US
dc.identifier.endpage198en_US
dc.identifier.issn2636-7688
dc.identifier.issue2en_US
dc.identifier.startpage193en_US
dc.identifier.trdizinid285514en_US
dc.identifier.urihttps://doi.org/10.5455/jtomc.2018.01.021
dc.identifier.urihttps://hdl.handle.net/11616/42233
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/285514
dc.identifier.volume25en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isotren_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe effects of total parenteral nutrition on telomerase expression in rabbiten_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Yükleniyor...
Küçük Resim
İsim:
Makale Dosyası.pdf
Boyut:
1.06 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Doyası
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.71 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama: