The attenuation of vasospasm by using a SOD mimetic after experimental subarachnoidal haemorrhage in rats

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridAladag, M. Arif/0000-0003-3872-3741
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidAladag, M. Arif/ABI-1182-2020
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorAladag, MA
dc.contributor.authorTurkoz, Y
dc.contributor.authorSahna, E
dc.contributor.authorParlakpinar, H
dc.contributor.authorGul, M
dc.date.accessioned2024-08-04T20:13:22Z
dc.date.available2024-08-04T20:13:22Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. Delayed cerebral vasoconstriction and brain ischemia, are critical problems in the management of a patient affected by rupture of an intracranial aneurysm. Overexpression of Cu-Zn superoxide dismutase (Cu-Zn SOD) can reduce the extent of cerebral vasospasm. We, therefore investigated if vasospasm, can be prevented by a novel, stable, and cell permeable SOD mimetic, MnTBAP [Mn(III) tetrakis (4-benzoic acid) porphyrin] which permeates the biological membranes and scavenges superoxide anions and peroxynitrite. Methods. 28 rats (225-250 g) were divided equally into four groups: group 1: control; group 2: SAH only; group 3: SAH plus placebo; and group 4: SAH plus MnTBAP We used a double haemorrhage method to produce SAH. Starting six hours after SAH, 5 mg/kg MnTBAP (Calbiochem, Darmstadt-Germany; Cat. No 475870)) or an equal volume of 0.9% saline (37degreesC) was administered by intraperitoneal injection twice daily for 5 days to groups 4 and 3 respectively. MnTBAP or 0.9% saline injections were continued up to fifth day after SAH and rats were sacrificied on the fifth day. Brain sections at the level of the pons were examined by light microscopy. Planimetric measurements were made for the cross-sectional areas of the lumen and the vessel wall (intima plus media) of the basilar artery by a micrometer. Finding. Administration of MnTBAP significantly attenuated the vasoconstriction of the basilar artery in group 4 compared with the groups 2 and 3 (p<0.001). Interpretation. These results suggest that this SOD mimetic (MnTBAP) attenuates delayed cerebral vasoconstriction following experimental SAH and that superoxide anions have a role in the pathogenesis of vasospasm after SAH.en_US
dc.identifier.doi10.1007/s00701-003-0052-z
dc.identifier.endpage677en_US
dc.identifier.issn0001-6268
dc.identifier.issn0942-0940
dc.identifier.issue8en_US
dc.identifier.pmid14520547en_US
dc.identifier.scopus2-s2.0-0041328729en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage673en_US
dc.identifier.urihttps://doi.org/10.1007/s00701-003-0052-z
dc.identifier.urihttps://hdl.handle.net/11616/93576
dc.identifier.volume145en_US
dc.identifier.wosWOS:000185228000021en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Wienen_US
dc.relation.ispartofActa Neurochirurgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectraten_US
dc.subjectsubarachnoid haemorrhageen_US
dc.subjectvasospasmen_US
dc.subjectSOD mimeticen_US
dc.titleThe attenuation of vasospasm by using a SOD mimetic after experimental subarachnoidal haemorrhage in ratsen_US
dc.typeArticleen_US

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