Could Fetuin-A Be a Biomarker for Autism Spectrum Disorder and Cognitive Developmental Delay?

Basit Öğe Kaydı
dc.authoridYıldırım Demirdöğen, Esen/0000-0002-2457-5832
dc.authorwosidYıldırım Demirdöğen, Esen/HKV-7349-2023
dc.contributor.authorKurt, Nezahat
dc.contributor.authorOzgeris, Fatma B.
dc.contributor.authorUcuz, Ilknur
dc.contributor.authorBayraktutan, Zafer
dc.contributor.authorKocak Yilmaz, Kubra
dc.contributor.authorDemirdogen, Esen Yildirim
dc.contributor.authorCayir, Atilla
dc.date.accessioned2024-08-04T20:52:04Z
dc.date.available2024-08-04T20:52:04Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractEarly detection of cognitive developmental delay (CDD) and autism spectrum disorder (ASD) is challenging, despite the numerous scientific studies conducted and different therapeutic strategies. Lack of a biomarker for autism is a limiting factor for early diagnosis, which could provide better outcome with early start of therapy. Because of the high serum fetuin-A concentration during intrauterine life, it has been suggested that fetuin-A may have a role in brain development. The current study sought to determine if fetuin-A, a multifunctional glycoprotein thought to have a role in brain development, may be used as a biomarker for the diagnosis of ASD and developmental delay. The study involved 55 children with cognitive developmental delays and 40 healthy children. Two categories of children with cognitive developmental delays were identified. The participants were subjected to a psychiatric assessment as well as developmental testing. Only 54.5% of the 55 individuals had CDD, whereas 45.5% had ASD. Using an ELISA kit, the levels of serum fetuin-A were determined spectrophotometrically. The serum fetuin-A levels in the patients from the test group were found to be significantly lower than in the healthy individuals (p < 0.001). The cutoff value for the serum fetuin-A levels for cognitive developmental delay and autism spectrum disorder was 518 mu g/liter, according to the results of ROC analysis (84.6% sensitivity and 91.4% specificity, AUC: 0.95, p < 0.001). The findings suggest that the serum fetuin-A level may be used to diagnose autism spectrum disorder and cognitive developmental delays.en_US
dc.identifier.doi10.1134/S0006297922060074
dc.identifier.endpage565en_US
dc.identifier.issn0006-2979
dc.identifier.issn1608-3040
dc.identifier.issue6en_US
dc.identifier.pmid35790414en_US
dc.identifier.scopus2-s2.0-85132272868en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage559en_US
dc.identifier.urihttps://doi.org/10.1134/S0006297922060074
dc.identifier.urihttps://hdl.handle.net/11616/100724
dc.identifier.volume87en_US
dc.identifier.wosWOS:000812254000007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMaik Nauka/Interperiodica/Springeren_US
dc.relation.ispartofBiochemistry-Moscowen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectfetuin-Aen_US
dc.subjectautistic spectrum disorderen_US
dc.subjectcognitive developmental delayen_US
dc.subjectbiomarkeren_US
dc.subjectneurodevelopmental disorderen_US
dc.titleCould Fetuin-A Be a Biomarker for Autism Spectrum Disorder and Cognitive Developmental Delay?en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu