Potential Effects of Stem Cells Derived from the Peripheral Nerve and Adipose Tissue after the Nerve Crush Injury in Control and Obese Rats

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dc.authoridyildiran, alisan/0000-0002-2918-6238
dc.authoridBakirhan, Elfide Gizem/0000-0002-7401-2317
dc.authorwosidyildiran, alisan/A-6480-2019
dc.authorwosidBakirhan, Elfide Gizem/JQJ-1714-2023
dc.contributor.authorKustepe, Elif Kayhan
dc.contributor.authorAltunkaynak, Berrin Zuhal
dc.contributor.authorAlkan, Isinsu
dc.contributor.authorKivrak, Elfide Gizem
dc.contributor.authorYildiran, Alisan
dc.contributor.authorGeuna, Stefano
dc.date.accessioned2024-08-04T20:51:38Z
dc.date.available2024-08-04T20:51:38Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim of this study is to investigate effects of stem cells derived from the peripheral nerve and adipose tissues following the nerve crush injury in control and obese rats. For this aim, 41 Wistar Albino female rats were separated into eight equal groups; non-obese control (NOC) obese control (OC), non-obese injury (NOH), obese injury (OH), non-obese adipose (NOY), obese adipose (OY), non-obese nerve (NOPS), obese nerve (OPS). At the end of 8 weeks, all experimental animals without control groups were subjected to nerve crush procedure and sciatic nerve or fat stem cell homogenates were injected on the treatment group rats, and then, recovery process has been observed and histopathological, stereological, electrophysiological analyses and bioinformatic evaluation were made on removed sciatic nerves. Stereological results showed that adipose homogenate gave more successful results than peripheral nerve homogenates in the NOY group in comparison to the NOPS group in terms of myelinated axon number. Peripheral nerve homogenate has shown more successful results in the OPS group in comparison to the OY group. The number of unmyelinated axons was increased following treatment with adipose tissue homogenate in NOY and OY groups. In terms of myelin sheath thickness; we detected that treatments by peripheral nerve and especially adipose tissue homogenates lead to increase in the thickness of the axons of the peripheral nerves belong to the control and obese injury groups. All results showed that mesenchymal stem cell treatment by fresh tissue homogenates is successful in peripheral nerve regeneration and fat tissue is a considerable source of the stem cells for clinical applications.en_US
dc.identifier.doi10.1080/08941939.2021.1991530
dc.identifier.endpage1033en_US
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue5en_US
dc.identifier.pmid35094626en_US
dc.identifier.scopus2-s2.0-85124148728en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1021en_US
dc.identifier.urihttps://doi.org/10.1080/08941939.2021.1991530
dc.identifier.urihttps://hdl.handle.net/11616/100464
dc.identifier.volume35en_US
dc.identifier.wosWOS:000750134200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Investigative Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmesenchymal stem cellen_US
dc.subjectwhite adipose tissueen_US
dc.subjectfresh tissue homogenatesen_US
dc.subjectobesityen_US
dc.subjectnerve regenerationen_US
dc.titlePotential Effects of Stem Cells Derived from the Peripheral Nerve and Adipose Tissue after the Nerve Crush Injury in Control and Obese Ratsen_US
dc.typeArticleen_US

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