Can antibiotics affect the clinical features of patients with candidemia? The retrospective evaluation of 5 years of data in an intensive care unit

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dc.authoridÖzdemir, Nesligül/0000-0003-2551-9549
dc.authoridbicakcioglu, murat/0000-0001-9101-6857
dc.authoridguzel, sena/0000-0003-0818-2665
dc.authorwosidÖzdemir, Nesligül/ABH-5503-2020
dc.authorwosidOZER, Ayse B/R-8915-2018
dc.authorwosidbicakcioglu, murat/AAA-8149-2022
dc.contributor.authorDurmus, Mefkure
dc.contributor.authorKalkan, Serkan
dc.contributor.authorKarahan, Sena Guzel
dc.contributor.authorBicakcioglu, Murat
dc.contributor.authorOzdemir, Nesligul
dc.contributor.authorGun, Zeynep Ulku
dc.contributor.authorOzer, Ayse Belin
dc.date.accessioned2024-08-04T20:53:44Z
dc.date.available2024-08-04T20:53:44Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackgroundCandidemia is an opportunistic infection of intensive care units (ICUs) and causes morbidity and mortality. Multiple antibiotic exposure was found to be an independent risk factor for mortality and non-albicans candidemia (NAC) in candidemia patients. AimThe aim of this study was to determine the relationship between antibiotics and clinical features of patients with candidemia, and to determine the independent risk factors for hospital stay >50 days, 30-day mortality in hospital, candidemia types, and septic shock in candidemia patients. MethodsPatients were evaluated retrospectively for 5 years. A total of 148 candidemia cases were detected and included in the study. Characteristics of cases were defined and recorded. The relationship between qualitative data was determined by the chi(2) test. Logistic regression analysis was used to determine the independent risk factors for hospital stay >50 days, 30-day mortality in hospital, candidemia types, and septic shock in candidemia patients. ResultsThe incidence of candidemia for 5 years was 4.5%. Candida parapsilosis was the most reported species with 65% (n=97). Linezolid and central venous catheters (CVC) were found to be independent risk factors for NAC. Carbapenems and cephalosporins were found in association to lower mortality. No antibiotics or characteristics were found to be independent risk factors for mortality. Some broad spectrum antibiotics and antibiotic combinations were found in relationship with hospital stay >50 days; however, none of them were found to be independent risk factors. Metisilin resistant staphylococcus aureus (MRSA) antibiotics, meropenem+linezolid piperacillin-tazobactam+fluoroquinolones and comorbidity were found in association with septic shock, although only piperacillin-tazobactam+fluoroquinolones and comorbidity were found to be independent risk factors for septic shock. ConclusionsThis study concluded that many antibiotics were safe for candidemia patients. However, clinicians should pay attention when prescribing linezolid or piperacillin-tazobactam and flouroquinolons concomitantly or sequentially for patients with candidemia risk factors.en_US
dc.identifier.doi10.1136/ejhpharm-2022-003673
dc.identifier.issn2047-9956
dc.identifier.issn2047-9964
dc.identifier.pmid37098442en_US
dc.identifier.scopus2-s2.0-85160262851en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1136/ejhpharm-2022-003673
dc.identifier.urihttps://hdl.handle.net/11616/101373
dc.identifier.wosWOS:000981542600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmj Publishing Groupen_US
dc.relation.ispartofEuropean Journal of Hospital Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectepidemiologyen_US
dc.subjectcritical careen_US
dc.subjectpharmacy serviceen_US
dc.subjecthospitalen_US
dc.subjectmycologyen_US
dc.subjectdrug-related side effects and adverse reactionsen_US
dc.titleCan antibiotics affect the clinical features of patients with candidemia? The retrospective evaluation of 5 years of data in an intensive care uniten_US
dc.typeArticleen_US

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