The effect of long-term therapy with sodium valproate on oxidant/antioxidant status in epileptic children

Basit Öğe Kaydı
dc.authoridAslan, Mehmet/0000-0001-5710-6592
dc.authoridÇAKMAK, Ecir Ali/0000-0003-2735-2105
dc.authoridYakıncı, Mehmet Cengiz/0000-0001-5930-4269
dc.authorwosidAslan, Mehmet/AEL-7823-2022
dc.authorwosidÖZEROL, ELİF/AAA-6707-2021
dc.authorwosidÇAKMAK, Ecir Ali/HSH-2722-2023
dc.authorwosidYakıncı, Mehmet Cengiz/ABI-7519-2020
dc.contributor.authorOzerol, E
dc.contributor.authorAslan, M
dc.contributor.authorCakmak, EA
dc.contributor.authorGulec, M
dc.contributor.authorYakinci, C
dc.contributor.authorAkyol, O
dc.date.accessioned2024-08-04T20:13:19Z
dc.date.available2024-08-04T20:13:19Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAntiepileptic drugs may cause the changes in the oxidant/antioxidant status of the body. Reactive oxygen species have been suggested to be an important factor in the pathogenesis of various diseases as well as drug interactions and/or adverse effects. The aim of this study, therefore, is to investigate the status of major antioxidant enzyme activities as well as the end products of lipid peroxidation in erythrocyte and plasma from epileptic children after therapy with sodium valproate (VPA). Superoxide dismutase (SOD), catalase (CAT) activities and malondialdehyde (MDA) levels in erythrocyte and plasma were analyzed in 41 epileptic patients under long-term antiepileptic therapy with VPA and 32 healthy controls. Erythrocyte SOD activity was found to be increased (p=0.024) whereas erythrocyte CAT activity decreased (p=0.016) in patients with epilepsy under VPA treatment compared to the controls. MDA levels in erythrocyte were found to be markedly decreased in epileptic children compared to controls (p<0.001). In conclusion, decreased CAT activity seems to be compensated with increased SOD activity in erythrocytes protecting erythrocyte membranes from lipid peroxidation in patients with epilepsy under VPA treatment.en_US
dc.identifier.doi10.1002/nrc.10066
dc.identifier.endpage122en_US
dc.identifier.issn0893-6609
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-0037879436en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage115en_US
dc.identifier.urihttps://doi.org/10.1002/nrc.10066
dc.identifier.urihttps://hdl.handle.net/11616/93538
dc.identifier.volume32en_US
dc.identifier.wosWOS:000182492100006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofNeuroscience Research Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectvalproateen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectcatalaseen_US
dc.subjectmalondialdehydeen_US
dc.subjectepilepsyen_US
dc.titleThe effect of long-term therapy with sodium valproate on oxidant/antioxidant status in epileptic childrenen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu