Lenograstim versus filgrastim in mobilization before autologous hematopoietic stem cell transplantation in patients with multiple myeloma and lymphoma-Single center experience

Basit Öğe Kaydı
dc.authoridKAYA, Emin/0000-0001-8605-8497
dc.authoridSARICI, Ahmet/0000-0002-5916-0119
dc.authoridBİÇİM, SOYKAN/0000-0001-7498-344X
dc.authoridBahçecioğlu, Ömer Faruk/0000-0002-4045-4555
dc.authoridErkurt, Mehmet Ali/0000-0002-3285-417X
dc.authoridBERBER, Ilhami/0000-0003-3312-8476
dc.authorwosidKAYA, Emin/W-2951-2017
dc.authorwosidSARICI, Ahmet/ABI-7512-2020
dc.authorwosidBİÇİM, SOYKAN/ACZ-6163-2022
dc.authorwosidBahçecioğlu, Ömer Faruk/AAA-7477-2021
dc.authorwosidErkurt, Mehmet Ali/ABI-7232-2020
dc.authorwosidBERBER, Ilhami/ABI-6231-2020
dc.contributor.authorSarici, Ahmet
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorBahcecioglu, Omer Faruk
dc.contributor.authorBicim, Soykan
dc.contributor.authorBerber, Ilhami
dc.contributor.authorGok, Selim
dc.contributor.authorKaya, Emin
dc.date.accessioned2024-08-04T20:49:29Z
dc.date.available2024-08-04T20:49:29Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective Peripheral blood stem cell transplantation is frequently used in the treatment of various hematological malignancies after intensive chemotherapy. The primary aim of our study is to compare the amount of collected CD34+ cells and engraftment times in patients mobilized with filgrastim or lenograstim. Material and Methods Demographic and clinical data of multiple myeloma (MM) and lymphoma patients who underwent autologous transplantation and mobilized with G-CSF (filgrastim or lenograstim) without chemotherapy were collected retrospectively. Results One hundred eleven MM and 58 lymphoma patients were included in the study. When mobilization with filgrastim and lenograstim was compared in MM patients, there was no significant difference in neutrophil and thrombocyte engraftment times of lenograstim and filgrastim groups (p = 0.931 p = 0.135, respectively). Similarly, the median number of CD34+ cells collected in patients receiving filgrastim and lenograstim was very similar (4.2 x 10(6)/kg vs 4.3 x 10(6)/kg, p = 0.977). When compared with patients who received lenalidomide before transplantation and patients who did not receive lenalidomide, the CD34+ counts of the two groups were similar. However, neutrophil and platelet engraftment times in the group not receiving lenalidomide tended to be shorter (p = 0.095 and p = 0.12, respectively). When lymphoma patients mobilized with filgrastim and lenograstim were compared, neutrophil engraftment time (p = 0.498), thrombocyte engraftment time (p = 0.184), collected CD34+ cell counts (p = 0.179) and mobilization success (p = 0.161) of the groups mobilized with filgrastim and lenograstim were similar. Conclusion The superiority of the two agents to each other could not be demonstrated. Multi-center prospective studies with larger numbers of patients are needed.en_US
dc.identifier.doi10.1016/j.transci.2021.103127
dc.identifier.issn1473-0502
dc.identifier.issn1878-1683
dc.identifier.issue4en_US
dc.identifier.pmid33863669en_US
dc.identifier.scopus2-s2.0-85104402512en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.transci.2021.103127
dc.identifier.urihttps://hdl.handle.net/11616/99889
dc.identifier.volume60en_US
dc.identifier.wosWOS:000686760900010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTransfusion and Apheresis Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHematopoietic stem cell transplantationen_US
dc.subjectLenograstimen_US
dc.subjectFilgrastimen_US
dc.subjectMultiple myelomaen_US
dc.subjectLymphomaen_US
dc.titleLenograstim versus filgrastim in mobilization before autologous hematopoietic stem cell transplantation in patients with multiple myeloma and lymphoma-Single center experienceen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu