Effects of montelukast on burn wound healing in a rat model

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dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authoridOguzturk, Hakan/0000-0002-9800-1428
dc.authoridTurtay, Muhammet Gokhan/0000-0002-1728-8237
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidoguzturk, hakan/Q-6242-2019
dc.authorwosidÇOLAK, CEMİL/ABI-3261-2020
dc.authorwosidFirat, Cemal/D-1292-2012
dc.authorwosidOguzturk, Hakan/AAC-3915-2021
dc.authorwosidTurtay, Muhammet Gokhan/ABG-7401-2020
dc.contributor.authorTurtay, Muhammet G.
dc.contributor.authorFirat, Cemal
dc.contributor.authorSamdanci, Emine
dc.contributor.authorOguzturk, Hakan
dc.contributor.authorErbatur, Serkan
dc.contributor.authorColak, Cemil
dc.date.accessioned2024-08-04T20:32:41Z
dc.date.available2024-08-04T20:32:41Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: Montelukast, a selective cysteinyl leukotriene D(4)-receptor antagonist, is used in the treatment of asthma. In a rat model, our aim was to investigate the effects of montelukast, alone or in combination with topical antibiotics, on local burn wound healing. Methods: Rats were randomly allocated to four groups after local burn development: Group 1; rats were left to secondary healing without treatment, Group 2; a dose of 10 mg/ kg montelukast was given by gastric gavage once a day for 10 days, Group 3; rats were treated with topical pomade (bacitracin neomycin sulphate), and Group 4; rats were treat with a combination of topical antibiotic and montelukast (10 mg/kg were given by gastric gavage once a day for 10 days). Skin biopsies were taken on days 3, 10, 14, and 20 relative to burn induction. Results: Reepithelialization in the pomade and montelukast+pomade groups on the 10(th) day was significantly greater, in comparison with control and montelukast groups (p<0.05). For the montelukast group, edema (on the 14(th) day) and angiogenesis, fibroblast proliferation, edema and macrophage infiltration (on the 20(th) day) were statistically improved in comparison with the control group (p<0.05). For the montelukast+pomade group, angiogenesis, fibroblast proliferation and macrophage infiltration (on the 10th day), and angiogenesis, fibroblast proliferation, edema and macrophage infiltration (on the 14th and 20th days) were statistically improved in comparison with the control group (p<0.05). Conclusion: In conclusion, montelukast was effective on burn wound healing. Moreover, the effect was amplified when combined with topical antibiotics applied in the early stage of burn wound healing.en_US
dc.identifier.endpageE421en_US
dc.identifier.issn0147-958X
dc.identifier.issue6en_US
dc.identifier.pmid21134344en_US
dc.identifier.scopus2-s2.0-78751534275en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpageE413en_US
dc.identifier.urihttps://hdl.handle.net/11616/95235
dc.identifier.volume33en_US
dc.identifier.wosWOS:000285650200010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCanadian Soc Clinical Investigationen_US
dc.relation.ispartofClinical and Investigative Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectReceptor Blocker Montelukasten_US
dc.subjectInduced Oxidative Injuryen_US
dc.subjectThermal-Injuryen_US
dc.subjectInflammationen_US
dc.subjectMacrophagesen_US
dc.titleEffects of montelukast on burn wound healing in a rat modelen_US
dc.typeArticleen_US

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