Results of Intrahepatic Cholangiocarcinoma Resections: a Single-Center Analysis

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dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridBag, Yusuf Murat/0000-0002-0159-9356
dc.authoridSaglam, Kutay/0000-0002-0919-8370
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidBag, Yusuf Murat/ABD-2949-2021
dc.authorwosidSaglam, Kutay/ACN-1173-2022
dc.contributor.authorSaglam, Kutay
dc.contributor.authorBag, Yusuf Murat
dc.contributor.authorBilen, Zafer
dc.contributor.authorIsik, Burak
dc.contributor.authorAydin, Cemalettin
dc.contributor.authorYilmaz, Sezai
dc.date.accessioned2024-08-04T20:51:35Z
dc.date.available2024-08-04T20:51:35Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction Intrahepatic cholangiocarcinoma (ICC) is the second most common primary neoplasm of the liver after hepatocellular carcinoma (HCC). Although an underlying cause is not usually found, liver flukes, cirrhosis, primary sclerosing cholangitis, and viral hepatitis have been found to increase the risk in recent years. In this study, we aimed to present our experience on ICC and compare the outcomes of patients with a concomitant liver pathology and with incidentally detected ICC. Patients and Methods Thirty-three patients who underwent surgical resection for ICC were included in the study. Patients were divided into two groups, group one (with concomitant liver disease, n = 13) and group two (incidentally detected ICC, n = 18). Demographics, perioperative findings, pathological properties, recurrence rates, and survival rates were retrospectively analyzed and compared between the groups. Results The mean age of patients was 59.77 +/- 9.81 years, of whom sixteen (51.6%) were males. Thirteen patients (41.9%) had concomitant liver disease, the most common being chronic hepatitis B infection. Eighteen patients (58.1%) had incidentally detected ICC. There were no significant differences between the groups except for follow-up time and recurrence rate. The recurrence rate was significantly higher in the incidentally detected ICC group (61.1% versus 7.7%, p = 0.003). Follow-up time was significantly higher in patients with concomitant liver disease (42 versus 17.5 months, p = 0.007). The mortality rate was higher in the incidentally detected ICC group (55.6 to 23.1%, p = 0.071) but the difference did not reach statistical significance. Conclusion Surgical resection in ICC patients with underlying liver disease is associated with better prognosis than in incidentally detected ICC patients. Incidental ICC may be a different tumor with different biology, hence the high recurrence rates.en_US
dc.identifier.doi10.1007/s12029-021-00781-0
dc.identifier.endpage1039en_US
dc.identifier.issn1941-6628
dc.identifier.issn1941-6636
dc.identifier.issue4en_US
dc.identifier.pmid34989985en_US
dc.identifier.scopus2-s2.0-85122434729en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1034en_US
dc.identifier.urihttps://doi.org/10.1007/s12029-021-00781-0
dc.identifier.urihttps://hdl.handle.net/11616/100399
dc.identifier.volume53en_US
dc.identifier.wosWOS:000739798000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Gastrointestinal Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLiveren_US
dc.subjectCholangiocytesen_US
dc.subjectTumoren_US
dc.subjectHepatic malignanciesen_US
dc.titleResults of Intrahepatic Cholangiocarcinoma Resections: a Single-Center Analysisen_US
dc.typeArticleen_US

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