The relationship between serum FGF-23 concentration and insulin resistance, prediabetes and dyslipidemia in obese children and adolescents

Basit Öğe Kaydı
dc.authoridAkinci, Aysehan/0000-0001-7267-9444
dc.authoridYologlu, Saim/0000-0002-9619-3462;
dc.authorwosidAkinci, Aysehan/AAC-6847-2021
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidÖzerol, İbrahim Halil/ABI-8015-2020
dc.contributor.authorKutluturk, Yesim
dc.contributor.authorAkinci, Aysehan
dc.contributor.authorOzerol, Ibrahim Halil
dc.contributor.authorYologlu, Saim
dc.date.accessioned2024-08-04T20:46:01Z
dc.date.available2024-08-04T20:46:01Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Obesity is known to cause metabolic disturbances including insulin resistance, dyslipidemia and alters bone mineralization. The effects of obesity on fibroblast growth factor 23 (FGF-23), which is important in bone mineralization, have not yet been clarified. Our aim was to investigate the association between FGF-23 concentration and obesity-associated dysmetabolism. Methods: Subjects comprised 46 obese children and adolescents. The same number of age-matched, healthy controls were recruited. Markers of bone mineralization and glucose metabolism were measured. Thyroid function and insulin resistance were investigated in both groups. In obese subjects; an oral glucose tolerance test (OGTT) was performed and hemoglobin A(1c) and lipid fractions were measured. Bone mineral density and hepatic steatosis were investigated. Results: Serum FGF-23, alpha-klotho and 1,25(OH)(2)D-3 concentrations were significantly lower while fasting insulin, fasting glucose, C-peptide and alkaline phosphatase (ALP) concentrations and homeostasis model assessment of insulin resistance (HOMA-IR) were significantly higher in the obese group compared to controls. A significant negative correlation was observed between free tri-iodothyronine (fT3) and both FGF-23 and alpha-klotho in the obese group. Significant negative correlation was found between FGF-23 and C-peptide and a positive correlation was found between FGF-23 and high density lipoprotein-cholesterol (HDL-c) in the obese subjects with impaired glucose tolerance (IGT). Significant negative correlations were found between FGF-23 and both fasting insulin levels and C-peptide levels in the obese subjects with hepatic steatosis. Conclusions: In our study, insulin resistance-associated hyperinsulinism and/or lower 1,25(OH)(2)D-3 levels, both present in obese children and adolescents, may lead to decreased serum FGF-23 concentrations in obese subjects.en_US
dc.description.sponsorshipDepartment of Scientific Research, Inonu University [2013/95]en_US
dc.description.sponsorshipDepartment of Scientific Research, Inonu University, Grant Number: 2013/95.en_US
dc.identifier.doi10.1515/jpem-2018-0507
dc.identifier.endpage714en_US
dc.identifier.issn0334-018X
dc.identifier.issn2191-0251
dc.identifier.issue7en_US
dc.identifier.pmid31211688en_US
dc.identifier.scopus2-s2.0-85068002620en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage707en_US
dc.identifier.urihttps://doi.org/10.1515/jpem-2018-0507
dc.identifier.urihttps://hdl.handle.net/11616/98846
dc.identifier.volume32en_US
dc.identifier.wosWOS:000474203700007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofJournal of Pediatric Endocrinology & Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectalpha-klothoen_US
dc.subjectFGF-23en_US
dc.subjectinsulin resistanceen_US
dc.subjectobesityen_US
dc.subjectprediabetesen_US
dc.titleThe relationship between serum FGF-23 concentration and insulin resistance, prediabetes and dyslipidemia in obese children and adolescentsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu