Protective effect of quercetin against oxidative stress-induced toxicity associated with doxorubicin and cyclophosphamide in rat kidney and liver tissue

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dc.authorscopusid54784629200
dc.authorscopusid26867577800
dc.authorscopusid56319905700
dc.authorscopusid36543258600
dc.contributor.authorKocahan S.
dc.contributor.authorDogan Z.
dc.contributor.authorErdemli E.
dc.contributor.authorTaskin E.
dc.date.accessioned2024-08-04T20:02:34Z
dc.date.available2024-08-04T20:02:34Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction. Doxorubicin and cyclophosphamide are widely used anticancer drugs with substantial toxicity in noncancerous tissue resulting from oxidative damage. Quercetin is a potent antioxidant compound. We hypothesized that quercetin administration would ameliorate the toxic effects of doxorubicin and cyclophosphamide prior to pregnancy. Materials and Methods. Cyclophosphamide, 27 mg/kg, and doxorubicin, 1.8 mg/kg, were administered to rats as intraperitoneal doses once every 3 weeks for a total of 10 weeks with or without concurrent treatment with quercetin, 10 mg/kg/d. Oxidative stress parameters were evaluated in maternal kidney and liver tissues after gestation. Results. Doxorubicin was associated with elevated kidney tissue malondialdehyde relative to the controls and quercetin only treatment (P <.05). Both cyclophosphamide and doxorubicin were associated with elevated malondialdehyde levels in the liver tissue (P <.05). Doxorubicin treatment was associated with decreased liver glutathione peroxidase (P <.05). Quercetin treatment suppressed the accumulation of malondialdehyde and increased glutathione peroxidase levels during doxorubicin and cyclophosphamide treatment (P <.05) Conclusions. Treatment with quercetin in patients receiving doxorubicin and cyclophosphamide results in therapeutic restoration of homeostatic expression of the antioxidant parameters, reducing oxidative damage to the liver and kidney. © 2017, Iranian Society of Nephrology. All rights reserved.en_US
dc.identifier.endpage131en_US
dc.identifier.issn1735-8582
dc.identifier.issue2en_US
dc.identifier.pmid28270644en_US
dc.identifier.scopus2-s2.0-85014778238en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage124en_US
dc.identifier.urihttps://hdl.handle.net/11616/91790
dc.identifier.volume11en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIranian Society of Nephrologyen_US
dc.relation.ispartofIranian Journal of Kidney Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclophosphamideen_US
dc.subjectDoxorubicinen_US
dc.subjectKidneyen_US
dc.subjectLiveren_US
dc.subjectOxidative stressen_US
dc.subjectQuercetinen_US
dc.titleProtective effect of quercetin against oxidative stress-induced toxicity associated with doxorubicin and cyclophosphamide in rat kidney and liver tissueen_US
dc.typeArticleen_US

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