Effects of nucleoside analogues on liver regeneration 70% partially hepatectomized rats

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dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridAlan, Saadet/0000-0003-2329-151X
dc.authoridYILMAZ, Mehmet/0000-0002-5710-5263
dc.authoridKayaalp, Cuneyt/0000-0003-4657-2998
dc.authorwosidYilmaz, Mehmet/AAF-6095-2021
dc.authorwosidKayaalp, Cuneyt/AAH-1764-2021
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidAlan, Saadet/ABH-4282-2020
dc.authorwosidYILMAZ, Mehmet/HKM-4739-2023
dc.contributor.authorYilmaz, S
dc.contributor.authorKirimlioglu, V
dc.contributor.authorKirimlioglu, H
dc.contributor.authorCoban, S
dc.contributor.authorKayaalp, C
dc.contributor.authorYilmaz, M
dc.contributor.authorKarakoc, Y
dc.date.accessioned2024-08-04T20:15:21Z
dc.date.available2024-08-04T20:15:21Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description8th Meeting of the Turkish-Transplantation-Society -- JUN 22-24, 2005 -- Ankara, TURKEYen_US
dc.description.abstractThe alternatives for prophlaxis and treatment of recurrent hepatitis B virus infection have increased since new oral nucleoside analogues have become available. We conducted this experimental study to investigate the effect in the liver of these agents on the expression of transforming growth factor alpha (TGF-alpha) and on proliferation index, estimated by Ki-67. Thirty male Wistar albino rats were randomized into three groups: group A (n = 10) received adefovir dipivoxil (40 mg/kg/d per gavage); group B (n = 10), lamivudine (L; 30 mg/kg/d per gavage); and group C (n = 10) did not receive any treatment and were the control group. Groups A and B were treated for 3 days. Animal treatment began on day -1. After performing 70% partial hepatectomy on day 0, all rats were sacrificed on postoperative day 2 to harvest liver tissues for histopathological examination. We stained and indexed Ki-67 and TGF-alpha immunohistochemically on the hepatectomy surface and in the parenchyma, Ki-67 and TGF-a indices were significantly higher in group A compared with group B (P = .001 and P = .004, respectively, and P = .003 and P = .001, respectively). When the L group was compared with the control group for results on the hepatectomy surface and the parenchyma, Ki-67 and TGF-a indexes were insignificantly different (P = .6 and P = .3, respectively, and P = .1 and P = .6, respectively). Based on the results of this experimental study, we concluded that Adefovir dipivoxil has greater proliferative effect on liver parenchyma and in the cut surface than does lamivudine.en_US
dc.description.sponsorshipTurkish Transplantat Socen_US
dc.identifier.doi10.1016/j.transproceed.2006.01.021
dc.identifier.endpage570en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue2en_US
dc.identifier.pmid16549177en_US
dc.identifier.scopus2-s2.0-33645083744en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage568en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2006.01.021
dc.identifier.urihttps://hdl.handle.net/11616/94320
dc.identifier.volume38en_US
dc.identifier.wosWOS:000236440100061en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic Hepatitis-Ben_US
dc.subjectAdefovir Dipivoxilen_US
dc.subjectLamivudineen_US
dc.subjectTransplantationen_US
dc.subjectTherapyen_US
dc.titleEffects of nucleoside analogues on liver regeneration 70% partially hepatectomized ratsen_US
dc.typeConference Objecten_US

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