Hesperidin protects brain and sciatic nerve tissues against cisplatin induced oxidative histological and electromyographical side effects in rats

Basit Öğe Kaydı
dc.contributor.authorKamışlı, Suat
dc.contributor.authorÇiftçi, Osman
dc.contributor.authorKaya, Kürşat
dc.contributor.authorÇetin, Aslı
dc.contributor.authorKamışlı, Özden
dc.contributor.authorÖzcan, Abdulcemal
dc.date.accessioned2017-05-19T08:45:17Z
dc.date.available2017-05-19T08:45:17Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn the present study, the beneficial effect of hesperidin (HP), a citrus flavonoid, on cisplatin (CP)-induced neurotoxicity was investigated. A total of 28 rats were equally divided into four groups; the first group was kept as control. In the second and third groups, CP and HP were given at the doses of 7 and 50 mg/kg/day, respectively. In the fourth group, CP and HP were given together at the same doses. The results indicated that although CP caused significant induction of lipid peroxidations and reduction in the antioxidant defense system potency in the brain and sciatic nerve, HP prevented these effects of CP. Besides, CP led to histopathological damage, mainly apoptosis, as well as electromyographical (EMG) changes in sciatic nerve. On the other hand, HP treatment reversed histopathological and EMG effects of CP. In conclusion, CP had severe dose-limiting neurotoxic effects and these effects of CP can be prevented by HP treatment. Thus, it appears that coadministration of HP with CP may be a useful approach to attenuate the negative effects of CP on the nervous system.en_US
dc.identifier.citationKamışlı, S. Çiftçi, O. Kaya, K. Çetin, A. Kamışlı, Ö. Özcan, A. (2015). Hesperidin protects brain and sciatic nerve tissues against cisplatin induced oxidative histological and electromyographical side effects in rats. Toxicology and Industrial Health. 31(9), 841–851.en_US
dc.identifier.doi10.1177/0748233713483192en_US
dc.identifier.endpage851en_US
dc.identifier.issn0748-2337
dc.identifier.issue9en_US
dc.identifier.startpage841en_US
dc.identifier.urihttp://tih.sagepub.com/cgi/doi/10.1177/0748233713483192
dc.identifier.urihttps://hdl.handle.net/11616/6904
dc.identifier.volume31en_US
dc.language.isoenen_US
dc.publisherToxicology and Industrial Healthen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCisplatinen_US
dc.subjectHesperidinen_US
dc.subjectNeurotoxic effecten_US
dc.subjectOxidative damageen_US
dc.subjectElectromyographyen_US
dc.titleHesperidin protects brain and sciatic nerve tissues against cisplatin induced oxidative histological and electromyographical side effects in ratsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Makale Dosyası.pdf
Boyut:
1.93 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.71 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Tıp Fakültesi, Nöroloji Anabilim Dalı Koleksiyonu