First electrochemical analysis of acalabrutinib via heterostructure porous carbon matrix contains multimetals

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dc.contributor.authorBugday, Nesrin
dc.contributor.authorGenc, Asena Ayse
dc.contributor.authorBouali, Wiem
dc.contributor.authorErk, Nevin
dc.contributor.authorYasar, Sedat
dc.date.accessioned2026-04-04T13:35:08Z
dc.date.available2026-04-04T13:35:08Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractA novel electrochemical sensor based on a NiZn/Co heterostructure embedded in nitrogen-doped porous carbon (NiZn/Co@NPC) was successfully developed for the sensitive determination of Acalabrutinib (ACA). The NiZn/ Co@NPC nanocomposite was synthesized using Ni/Zn@ZIF as a precursor, ensuring the uniform dispersion of nanoparticles within the porous carbon matrix, as confirmed by XRD, SEM, and TEM analyses. The incorporation of multi-metallic active sites and the high surface area of the porous carbon significantly enhanced electron transfer, minimized nanoparticle aggregation, and improved electrochemical performance. The NiZn/Co@NPCmodified glassy carbon electrode (NiZn/Co@NPC/GCE) exhibited superior sensitivity compared to the bare electrode, with a wide linear detection range (0.5-5.0 mu M), a low detection limit (0.03 mu M), and excellent repeatability (RSD = 1.4 %) and reproducibility (RSD = 2.0 %). The sensor demonstrated high selectivity against potential interferents, confirming its robustness for real-world applications. Analytical validation in pharmaceutical capsules, spiked urine, and plasma samples using the standard addition method yielded recoveries ranging from 99.4 % to 101.9 %, confirming the accuracy and reliability of the electrochemical method. The incorporation of multi-metallic active sites and creation of more electroactive surface area in the porous carbon by doping different redox active metals leads to significantly enhanced charge transfer, minimized nanoparticle aggregation, and improved electrochemical performance.
dc.description.sponsorshipScientific Research Project Office of Ankara University (A.UE. BAP) [TDK-2023-3036/TSA-2025-3888/TSA-2023-2738]; Scientific Research Project Office of Inonue UEniversity [FYL-2024-3599]
dc.description.sponsorshipThis work was supported by the Scientific Research Project Office of Ankara University (A.UE. BAP) (Project no: TDK-2023-3036/TSA-2025-3888/TSA-2023-2738) and Scientific Research Project Office of Inonue UEniversity (Project no: FYL-2024-3599) .
dc.identifier.doi10.1016/j.electacta.2025.146715
dc.identifier.issn0013-4686
dc.identifier.issn1873-3859
dc.identifier.orcid0009-0004-5096-6804
dc.identifier.scopus2-s2.0-105008292993
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.electacta.2025.146715
dc.identifier.urihttps://hdl.handle.net/11616/109643
dc.identifier.volume536
dc.identifier.wosWOS:001517094000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofElectrochimica Acta
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectAcalabrutinib
dc.subjectZIF-12
dc.subjectMultimetal porous carbon
dc.subjectElectrochemical detection
dc.subjectPharmaceutical and biological samples
dc.titleFirst electrochemical analysis of acalabrutinib via heterostructure porous carbon matrix contains multimetals
dc.typeArticle

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