Tip 2 Diyabetli Hastalarda Hbaıc İle Lipidler Ve Lipoprotein(A) Düzeyleri Arasındaki İlişkinin Araştırılması+
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Dosyalar
Tarih
1999
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turgut Özal Tıp Merkezi Dergisi
Erişim Hakkı
Attribution 3.0 United States
Özet
Çalışmamızda, tip 2 diyabetli hasta gruplarıyla sağlıklı kontrol grubu arasında lipoprotein(a) (Lp(a))ve lipid düzeyleri karşılaştırıldı. Kan şekeri ve HbAlc değerleri çok yüksek seyreden hasta grubu 6 ay süreyle takip ve tedavi edildi. HbAlc ve kan şekeri düzeyleri kabul edilebilir değerlere indirildiğinde, serum Lp(a) ve diğer aterojen lipid düzeylerinin hangi ölçüde değişim gösterdiği saptandı.
Tip 2 diyabetli, yaş ortalamaları 47.94±7.76 yıl olan 80 hasta (29 erkek ve 51 kadın) çalış-maya alındı. Hastalar HbA1c değerleri <%6, %6-8 ve >%8 olmak üzere üç gruba ayrıldı. HbA1c değerleri >%8 olan 52 hastanın 6 aylık takip ve tedavi sonuFunda kan şekerleri kabul edilebilir düzeylere indirildi. Çalışma kontrollü ve prospektif olarak düzenlendi.
Başlangıçta, tüm gruplar arasında Lp(a) düzeyleri yönünden anlamlı bir fark olmadığı sap-tandı. Altı ay sonunda, Lp(a) ve trigliserid düzeyleri arasında anlamlı bir fark saptanmadı. Total kolesterol, HDL- kolesterol ve LDL-kolesterol düzeylerinde ise anlamlı azalma saptandı. HbA1c ile tüm parametreler arasında anlamlı bir korelasyon saptanmadı.
Sonuç olarak, Lp(a) düzeylerinin tp 2 diyabetli hastalarda sağlıklı bireylerden farklı olma-dığı, diyabetteki kan şekeri ve lipid metabolizmasında yapılan iyileştirmelerin Lp(a) düzey-lerini etkilemediği, hastalarımızda genel olarak diyabette görülen dislipidemi özelliklerinin var olduğu, diyabetin medikal tedavisinin yanısıra diyetin ve diyetteki yöresel özelliklerin de hastaların lipid profili üzerinde etkili olduğu saptanmıştır.
In this study, we compared the lipid and Lipoprotein(a) levels in patients with type 2 diabetes mellitus with the patients in the control group. A group of patients with high serum glucose and HbA1c levels was followed up for six months following medical treatment. With the normalisation of blood glucose and HbA1c levels in this period, the difference in serum Lp(a) and other atherogenic lipid levels were determLned. Eighty patients (29 males and 51 females) with type 2 diabetes mellitus, aged 47.94 ± 7.76 years, were included in the study Patients were divided into three groups depending on HbA1c levels (< 6%, 6-8% and > 8%), Blood glucose levels were normalised at six months following treatment in 52 patients with HbA1c levels > 8%. The study was designed as a controlled and prospective study Prior to treatment, there were no significant differences in Lp(a) levels in all of the groups. After six months, there were still no significant differences in Lp(a) and triglyceride levels. However, there was a significant decrease in total cholesterol, HDL-cholesterol and LDL-cholesterol levels. Besides, there was no correlation between HbA1c levels and all other parameters. We conclude that there was no significant difference in Lp(a) levels in patients with type 2 diabetes and the patients in the control group. In addition, the improvement in serum glucose levels and lipid metabolsm in diabetes did not affect Lp(a) levels as the lipid profiles of our patients were similar to the characteristics of dyslipidemia in diabetes. Finally the lipid profile of patients with type 2 diabetes mellitus was also found to be affected by the regional differences in diet besides medical treatment.
In this study, we compared the lipid and Lipoprotein(a) levels in patients with type 2 diabetes mellitus with the patients in the control group. A group of patients with high serum glucose and HbA1c levels was followed up for six months following medical treatment. With the normalisation of blood glucose and HbA1c levels in this period, the difference in serum Lp(a) and other atherogenic lipid levels were determLned. Eighty patients (29 males and 51 females) with type 2 diabetes mellitus, aged 47.94 ± 7.76 years, were included in the study Patients were divided into three groups depending on HbA1c levels (< 6%, 6-8% and > 8%), Blood glucose levels were normalised at six months following treatment in 52 patients with HbA1c levels > 8%. The study was designed as a controlled and prospective study Prior to treatment, there were no significant differences in Lp(a) levels in all of the groups. After six months, there were still no significant differences in Lp(a) and triglyceride levels. However, there was a significant decrease in total cholesterol, HDL-cholesterol and LDL-cholesterol levels. Besides, there was no correlation between HbA1c levels and all other parameters. We conclude that there was no significant difference in Lp(a) levels in patients with type 2 diabetes and the patients in the control group. In addition, the improvement in serum glucose levels and lipid metabolsm in diabetes did not affect Lp(a) levels as the lipid profiles of our patients were similar to the characteristics of dyslipidemia in diabetes. Finally the lipid profile of patients with type 2 diabetes mellitus was also found to be affected by the regional differences in diet besides medical treatment.
Açıklama
Bu tezin, veri tabanı üzerinden yayınlanma izni bulunmamaktadır. Yayınlanma izni olmayan tezlerin basılı kopyalarına Üniversite kütüphaneniz aracılığıyla (TÜBESS üzerinden) erişebilirsiniz.
Anahtar Kelimeler
Tip 2 diyabet, ateroskleroz, lipoprotein(a), Type 2 diabetes mellitus, atherosclerosis, lipoprotein(a)
Kaynak
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Serbest, Servet ,Şavlı, Haluk , Sevinç, Alper ,Turgut Özal Tıp Merkezi Dergisi.6 (2) :1999. İnönü Üniversitesi, Malatya.
