Effect of permeability enhancers on paracellular permeability of acyclovir

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dc.authoridKAYNAK, Mustafa Sinan/0000-0003-2917-2407
dc.authoridAtes, Muge/0000-0001-9533-5791
dc.authorwosidKAYNAK, Mustafa Sinan/D-9453-2019
dc.authorwosidAteş, Müge/ABI-1317-2020
dc.authorwosidAteş, Müge/IZE-1782-2023
dc.contributor.authorAtes, Muge
dc.contributor.authorKaynak, Mustafa Sinan
dc.contributor.authorSahin, Selma
dc.date.accessioned2024-08-04T20:41:39Z
dc.date.available2024-08-04T20:41:39Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives According to Biopharmaceutics Classification System (BCS), acyclovir is a class III (high solubility, low permeability) compound, and it is transported through paracellular route by passive diffusion. The aim of this study was to investigate the effect of various pharmaceutical excipients on the intestinal permeability of acyclovir. Methods The single-pass in-situ intestinal perfusion (SPIP) method was used to estimate the permeability values of acyclovir and metoprolol across different intestinal segments (jejunum, ileum and colon). Permeability coefficient (P-eff) of acyclovir was determined in the absence and presence of a permeation enhancer such as dimethyl beta-cyclodextrin (DM-beta-CD), sodium lauryl sulfate (SLS), sodium caprate (Cap-Na) and chitosan chloride. Key findings All enhancers increased the permeability of paracellularly transported acyclovir. Although Cap-Na has the highest permeability-enhancing effect in all segments, permeation-enhancing effect of chitosan and SLS was only significant in ileum. On the other hand, DM-beta-CD slightly decreased the permeability in all intestinal segments. Conclusions These findings have potential implication concerning the enhancement of absorption of paracellularly transported compounds with limited oral bioavailability. In the case of acyclovir, Cap-Na either alone or in combination with SLS or chitosan has the potential to improve its absorption and bioavailability and has yet to be explored.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [111S335]en_US
dc.description.sponsorshipThis work was supported by The Scientific and Technological Research Council of Turkey (TUBITAK) [grant number 111S335].en_US
dc.identifier.doi10.1111/jphp.12551
dc.identifier.endpage790en_US
dc.identifier.issn0022-3573
dc.identifier.issn2042-7158
dc.identifier.issue6en_US
dc.identifier.pmid27061718en_US
dc.identifier.scopus2-s2.0-84963713719en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage781en_US
dc.identifier.urihttps://doi.org/10.1111/jphp.12551
dc.identifier.urihttps://hdl.handle.net/11616/97269
dc.identifier.volume68en_US
dc.identifier.wosWOS:000379941600006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Pharmacy and Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchitosanen_US
dc.subjectdimethyl beta-cyclodextrinen_US
dc.subjectsodium caprateen_US
dc.subjectsodium lauryl sulfateen_US
dc.subjectpermeation enhanceren_US
dc.titleEffect of permeability enhancers on paracellular permeability of acycloviren_US
dc.typeArticleen_US

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