Cyanopropyl functionalized benzimidazolium salts and their silver N-heterocyclic carbene complexes: Synthesis, antimicrobial activity, and theoretical analysis

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dc.authoridGünal, Selami/0000-0002-4752-5176
dc.authoridÜstün, Elvan/0000-0002-0587-7261
dc.authoridOzdemir, Ismail/0000-0001-6325-0216
dc.authorwosidGünal, Selami/AAA-7246-2021
dc.authorwosidÜstün, Elvan/HJB-1157-2022
dc.contributor.authorTurker, Dilek
dc.contributor.authorUstun, Elvan
dc.contributor.authorGunal, Selami
dc.contributor.authorYildiz, Hatice
dc.contributor.authorDusunceli, Serpil D.
dc.contributor.authorOzdemir, Ismail
dc.date.accessioned2024-08-04T20:51:50Z
dc.date.available2024-08-04T20:51:50Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe reaction of N-substituted benzimidazole with 4-bromobutyronitrile gives the corresponding benzimidazolium salts as N-heterocyclic carbene (NHC) precursors. Silver(I) carbene complexes are synthesized by the reaction of the corresponding benzimidazolium salts with Ag2O in dichloromethane. These new NHC precursors and Ag-NHC complexes were characterized by spectroscopy techniques and also screened for their antibacterial activities against the standard bacterial strains Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae, Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, and Enterococcus faecalis, and the standard fungal strains Candida albicans and Candida glabrata, and promising results were achieved. The compounds were also analyzed by density functional theory (DFT)/time-dependent DFT and docking methods.en_US
dc.description.sponsorshipInonu University [FYL-2018-1056, FBG-2021-2562]en_US
dc.description.sponsorshipThis study was financially supported by the Inonu University Research Fund (FYL-2018-1056 and FBG-2021-2562).en_US
dc.identifier.doi10.1002/ardp.202200041
dc.identifier.issn0365-6233
dc.identifier.issn1521-4184
dc.identifier.issue6en_US
dc.identifier.pmid35352839en_US
dc.identifier.scopus2-s2.0-85127487460en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/ardp.202200041
dc.identifier.urihttps://hdl.handle.net/11616/100586
dc.identifier.volume355en_US
dc.identifier.wosWOS:000774897000001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofArchiv Der Pharmazieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantibacterial activityen_US
dc.subjectbenzimidazolium saltsen_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectsilver-NHC complexen_US
dc.subjecttheoretical analysisen_US
dc.titleCyanopropyl functionalized benzimidazolium salts and their silver N-heterocyclic carbene complexes: Synthesis, antimicrobial activity, and theoretical analysisen_US
dc.typeArticleen_US

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