Radioembolization for Hepatocellular Carcinoma in Downstaging and Bridging for Liver Transplantation

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dc.contributor.authorKutlu, Ramazan
dc.contributor.authorKaratoprak, Sinan
dc.date.accessioned2024-08-04T20:48:54Z
dc.date.available2024-08-04T20:48:54Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose Hepatocellular carcinoma (HCC) is the most common primary liver tumor. Only about one third of them are eligible for curative treatments like liver transplantation. Various interventional oncologic treatment options could be employed for some of the HCC patients outside the acceptable liver transplantation criteria to make them suitable for transplantation by downstaging and keeping them inside the criteria by bridging to transplantation. Methods We reviewed the literature by the terms of downstaging and bridging therapy for liver transplantation. Results About only 30% of the patients are suitable for curative procedures like transplantation at the time of diagnosis of HCC. Even the Milan Criteria is expanded or new criteria are defined, still there are many patients who need downstaging to be eligible for transplantation. There are different procedures in interventional oncology for primary and metastatic liver lesions. Radioembolization (RE) is one of the locoregional therapies which is more effective than others for downstaging and bridging for liver transplantation. Conclusion Downstaging by RE is an effective and reasonable method for unresectable HCC cases initially beyond established criteria for liver transplantation by selecting suitable and favorable tumor biology.en_US
dc.identifier.doi10.1007/s12029-020-00492-y
dc.identifier.endpage1164en_US
dc.identifier.issn1941-6628
dc.identifier.issn1941-6636
dc.identifier.issue4en_US
dc.identifier.pmid32880041en_US
dc.identifier.scopus2-s2.0-85090191924en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1157en_US
dc.identifier.urihttps://doi.org/10.1007/s12029-020-00492-y
dc.identifier.urihttps://hdl.handle.net/11616/99514
dc.identifier.volume51en_US
dc.identifier.wosWOS:000565484400002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Gastrointestinal Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDownstagingen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectLiver transplanten_US
dc.subjectRadioembolizationen_US
dc.titleRadioembolization for Hepatocellular Carcinoma in Downstaging and Bridging for Liver Transplantationen_US
dc.typeReview Articleen_US

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