Modulating effects of selenium in adrenal medulla of rats exposed to 7,12-dimethylbenz[a]anthracene

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dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridYılmaz, İsmet/0000-0002-7204-1050
dc.authoridSelamoglu, Zeliha/0000-0001-9056-6435
dc.authorwosidYılmaz, ismet/AAG-8946-2019
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidÖzdemir, İlknur/AAA-6216-2021
dc.authorwosidYılmaz, İsmet/P-9976-2015
dc.contributor.authorTalas, Zeliha Selamoglu
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorAtes, Burhan
dc.contributor.authorGok, Yetkin
dc.contributor.authorYilmaz, Ismet
dc.date.accessioned2024-08-04T20:37:32Z
dc.date.available2024-08-04T20:37:32Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to evaluate the chemopreventive potential of organoselenium compounds (Se I and Se II) in the well-established rat model treated with 7,12-dimethylbenz[a]anthracene (DMBA), by monitoring the extent of tyrosine hydroxylase (TH) activity, adrenomedullin (ADM) level and total RNA level in adrenal medulla. Organic pollutants are the most important environmental factor for the biologic systems. DMBA exposure appears to be associated with a number of physiological disease processes. Methods: The effects of Se I and Se II compounds were investigated on TH activity, ADM and total RNA levels in adrenal medulla of rats exposed to DMBA. Results: TH activity, ADM and total RNA levels were found to be increased significantly due to the effect of DMBA (p < 0.05). This increase was restricted in the Se I-and Se II-treated groups (p < 0.05). Conclusion: The present data showed that the organoselenium compounds may have important effects in the maintainance of homeostasis against stress induced by DMBA.en_US
dc.description.sponsorshipInonu University [BAP 2005/60]en_US
dc.description.sponsorshipThis work was supported by Inonu University Research Fund (BAP 2005/60).en_US
dc.identifier.doi10.1177/0748233711432575
dc.identifier.endpage292en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue3en_US
dc.identifier.pmid22287620en_US
dc.identifier.scopus2-s2.0-84875751032en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage286en_US
dc.identifier.urihttps://doi.org/10.1177/0748233711432575
dc.identifier.urihttps://hdl.handle.net/11616/96002
dc.identifier.volume29en_US
dc.identifier.wosWOS:000317523000007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdrenal medullaen_US
dc.subjectadrenomedullinen_US
dc.subjectDMBAen_US
dc.subjectraten_US
dc.subjectsynthetic organoselenium compoundsen_US
dc.subjecttyrosine hydroxylaseen_US
dc.titleModulating effects of selenium in adrenal medulla of rats exposed to 7,12-dimethylbenz[a]anthraceneen_US
dc.typeArticleen_US

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