Histological and biochemical effects of dexmedetomidine on liver during an inflammatory bowel isease
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Ultrastructural Pathology
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Inflammation in the liver is an extraintestinal manifestation that is frequently seen during inflammatory bowel
diseases (IBD). The authors investigated histopathologycal, ultrastructural and antioxidant effects of
dexmedetomidine (Dex) on liver during trinitrobenzene sulfonic acid (TNBS)-induced inflammatory bowel
disease. Thirty-two BALB/c mice were divided (n = 8) as follows: control; Dex (dexmedetomidine) (30 mg/kg)
for 6 days; TNBS 150 mL, TNBS þ ethanol (50% w/v) intrarectally; TNBS þ Dex. The histopathological and
ultrastructural changes were evaluated. The levels of malondialdehyde (MDA), activity of antioxidant enzymes
(GPx and SOD) were measured in liver tissue. Induction of colitis induced histopathological and ultrastructural
changes of damage in liver. Those changes were markedly reduced in the TNBS þ Dex group and that reduction
was even significant in comparison to the TNBS group. MDA levels were significantly higher in the TNBS
group and dexmedetomidine significantly elevated SOD levels in the TNBS þ Dex group. These results suggest
that the administration of dexmedetomidine reduces the histopathological and ultrastructural damage and
increases the defense capacity against oxidative damage on liver in this IBD mice model.
Açıklama
Anahtar Kelimeler
Dexmedetomidine, Electron microscopy, Inflammation, Inflammatory bowel disease, Liver, Oxidative stress
Kaynak
Ultrastructural Pathology
WoS Q Değeri
Scopus Q Değeri
Cilt
39
Sayı
1
Künye
Gül, M. Kayhan, B. Elbe, H. Doğan, Z. Otlu, A. (2015). Histological and Biochemical Effects of Dexmedetomidine on Liver during an Inflammatory Bowel Disease. Ultrastructural Pathology, 39(1), 6–12.
