Histological and biochemical effects of dexmedetomidine on liver during an inflammatory bowel isease

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dc.authorid41809en_US
dc.contributor.authorGül, Mehmet
dc.contributor.authorKayhan, Başak
dc.contributor.authorElbe, Hülya
dc.contributor.authorDoğan, Zümrüt
dc.contributor.authorOtlu, Ali
dc.date.accessioned2017-08-01T06:44:51Z
dc.date.available2017-08-01T06:44:51Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractInflammation in the liver is an extraintestinal manifestation that is frequently seen during inflammatory bowel diseases (IBD). The authors investigated histopathologycal, ultrastructural and antioxidant effects of dexmedetomidine (Dex) on liver during trinitrobenzene sulfonic acid (TNBS)-induced inflammatory bowel disease. Thirty-two BALB/c mice were divided (n = 8) as follows: control; Dex (dexmedetomidine) (30 mg/kg) for 6 days; TNBS 150 mL, TNBS þ ethanol (50% w/v) intrarectally; TNBS þ Dex. The histopathological and ultrastructural changes were evaluated. The levels of malondialdehyde (MDA), activity of antioxidant enzymes (GPx and SOD) were measured in liver tissue. Induction of colitis induced histopathological and ultrastructural changes of damage in liver. Those changes were markedly reduced in the TNBS þ Dex group and that reduction was even significant in comparison to the TNBS group. MDA levels were significantly higher in the TNBS group and dexmedetomidine significantly elevated SOD levels in the TNBS þ Dex group. These results suggest that the administration of dexmedetomidine reduces the histopathological and ultrastructural damage and increases the defense capacity against oxidative damage on liver in this IBD mice model.en_US
dc.identifier.citationGül, M. Kayhan, B. Elbe, H. Doğan, Z. Otlu, A. (2015). Histological and Biochemical Effects of Dexmedetomidine on Liver during an Inflammatory Bowel Disease. Ultrastructural Pathology, 39(1), 6–12.en_US
dc.identifier.doi10.3109/01913123.2013.829150en_US
dc.identifier.endpage12en_US
dc.identifier.issn0191-3123
dc.identifier.issue1en_US
dc.identifier.startpage6en_US
dc.identifier.urihttp://www.tandfonline.com/doi/full/10.3109/01913123.2013.829150
dc.identifier.urihttps://hdl.handle.net/11616/7424
dc.identifier.volume39en_US
dc.language.isoenen_US
dc.publisherUltrastructural Pathologyen_US
dc.relation.ispartofUltrastructural Pathologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDexmedetomidineen_US
dc.subjectElectron microscopyen_US
dc.subjectInflammationen_US
dc.subjectInflammatory bowel diseaseen_US
dc.subjectLiveren_US
dc.subjectOxidative stressen_US
dc.titleHistological and biochemical effects of dexmedetomidine on liver during an inflammatory bowel iseaseen_US
dc.typeArticleen_US

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